Cacng7 MGI Mouse Gene Detail - MGI:1932374 - calcium channel, voltage-dependent, gamma subunit 7

Symbol

Cacng7
Name

calcium channel, voltage-dependent, gamma subunit 7
Synonyms

TARP gamma 7

Feature Type

protein coding gene
IDs

MGI:1932374
NCBI Gene: 81904
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr7:3381471-3416737 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 1.95 cM
Mapping Data

1 experiment

SNPs within 2kb

165 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932374	protein coding gene	Chr7:3381341-3416737 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031517	protein coding gene	Chr7:236042-283888 (+)
A/J	MGP_AJ_G0031492	protein coding gene	Chr7:240692-276281 (+)
AKR/J	MGP_AKRJ_G0031420	protein coding gene	Chr7:232405-268345 (+)
BALB/cJ	MGP_BALBcJ_G0031500	protein coding gene	Chr7:239158-274409 (+)
C3H/HeJ	MGP_C3HHeJ_G0031220	protein coding gene	Chr7:236649-276088 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031960	protein coding gene	Chr7:238746-282269 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029087	protein coding gene	Chr7:138854-173643 (+)
CAST/EiJ	MGP_CASTEiJ_G0030589	protein coding gene	Chr7:240726-278861 (+)
CBA/J	MGP_CBAJ_G0031180	protein coding gene	Chr7:329002-372089 (+)
DBA/2J	MGP_DBA2J_G0031337	protein coding gene	Chr7:230321-269754 (+)
FVB/NJ	MGP_FVBNJ_G0031289	protein coding gene	Chr7:232026-265635 (+)
LP/J	MGP_LPJ_G0031422	protein coding gene	Chr7:234751-276911 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031328	protein coding gene	Chr7:258835-302929 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031994	protein coding gene	Chr7:211665-260911 (+)
PWK/PhJ	MGP_PWKPhJ_G0030316	protein coding gene	Chr7:372933-410146 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030140	protein coding gene	Chr7:308450-343172 (+)
WSB/EiJ	MGP_WSBEiJ_G0030683	protein coding gene	Chr7:228682-268060 (+)

Human Ortholog

CACNG7, calcium voltage-gated channel auxiliary subunit gamma 7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CACNG7, calcium voltage-gated channel auxiliary subunit gamma 7
Links

HGNC:13626

NCBI Gene ID: 59284

neXtProt AC: NX_P62955

UniProt: P62955
Chr Location

19q13.42; chr19:53909278-53943950 (+) GRCh38

MGI Vertebrate Homology

Cacng7 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CACNG7
Gene Tree

Cacng7

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotypes from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

66
Endonuclease-mediated

2
Gene trapped

59
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available

Mice homozygous for a knock-out allele are viable, fertile, and indistinguishable from wild-type controls.

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All GO Annotations

41
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

780
Tissues

49
cDNA Data

13
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cacng7

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All Sequences

41
RefSeq

8
UniProt

3
CCDS

CCDS39725.1

Ensembl

ENSMUSG00000069806 (Evidence)
NCBI Gene

81904

			Length	Strain/Species	Flank
genomic	ENSMUSG00000069806	Ensembl Gene Model \| MGI Sequence Detail	35267	C57BL/6J	± kb
transcript	ENSMUST00000092891	Ensembl \| MGI Sequence Detail	2212	Not Applicable
polypeptide	ENSMUSP00000090567	Ensembl \| MGI Sequence Detail	275	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004956 voltage-dependent calcium channel gamma-7 subunit

(term hierarchy)
InterPro Domains

IPR004031 PMP-22/EMP/MP20/Claudin

IPR008371 Voltage-dependent calcium channel, gamma-7 subunit

IPR051072 Voltage-dependent calcium channel gamma subunit

IPR008368 Voltage-dependent calcium channel, gamma subunit

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All nucleic 14

Genomic 1

cDNA 13

Microarray probesets 3

Summaries

All 36

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 10
Earliest

J:67725 Burgess DL, et al., A Cluster of Three Novel Ca(2+) Channel gamma Subunit Genes on Chromosome 19q13.4: Evolution and Expression Profile of the gamma Subunit Gene Family. Genomics. 2001 Feb 1;71(3):339-50
Latest

J:344312 Liu H, et al., Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development. iScience. 2024 Jan 19;27(1):108722

TSS for Cacng7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64248	Chr7:3380514-3380592 (+)	-918 bp
Tssr64249	Chr7:3380650-3380684 (+)	-804 bp
Tssr64250	Chr7:3380688-3380726 (+)	-764 bp
Tssr64251	Chr7:3381305-3381353 (+)	-142 bp
Tssr64252	Chr7:3381434-3381466 (+)	-21 bp
Tssr64253	Chr7:3387330-3387358 (+)	5,873 bp
Tssr64254	Chr7:3414473-3414487 (+)	33,009 bp
Tssr64255	Chr7:3414692-3414704 (+)	33,227 bp
Tssr64256	Chr7:3414709-3414729 (+)	33,248 bp
Tssr64257	Chr7:3415393-3415407 (+)	33,929 bp
Tssr64258	Chr7:3415456-3415513 (+)	34,014 bp
Tssr64259	Chr7:3415896-3415918 (+)	34,436 bp
Tssr64260	Chr7:3415926-3415941 (+)	34,463 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24