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Ift122 Gene Detail
Summary
  • Symbol
    Ift122
  • Name
    intraflagellar transport 122
  • Synonyms
    C86139, sopb, Wdr10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932386
    NCBI Gene: 81896
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:115830431-115903660 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1539 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932386
 protein coding gene Chr6:115830340-115903660 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031158
 protein coding gene Chr6:118497656-118573300 (+)
A/J MGP_AJ_G0031128
 protein coding gene Chr6:113951069-114023148 (+)
AKR/J MGP_AKRJ_G0031058
 protein coding gene Chr6:117007349-117075013 (+)
BALB/cJ MGP_BALBcJ_G0031138
 protein coding gene Chr6:113755633-113828405 (+)
C3H/HeJ MGP_C3HHeJ_G0030570
 protein coding gene Chr6:67226329-67293858 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031597
 protein coding gene Chr6:121520811-121593591 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028761
 protein coding gene Chr6:110953051-111021830 (+)
CAST/EiJ MGP_CASTEiJ_G0030245
 protein coding gene Chr6:117381036-117450838 (+)
CBA/J MGP_CBAJ_G0030824
 protein coding gene Chr6:126293755-126364623 (+)
DBA/2J MGP_DBA2J_G0030978
 protein coding gene Chr6:112870726-112939445 (+)
FVB/NJ MGP_FVBNJ_G0030931
 protein coding gene Chr6:112050216-112119082 (+)
LP/J MGP_LPJ_G0031057
 protein coding gene Chr6:118507942-118576955 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030966
 protein coding gene Chr6:130457512-130527018 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031625
 protein coding gene Chr6:117029977-117100994 (+)
PWK/PhJ MGP_PWKPhJ_G0029961
 protein coding gene Chr6:111886901-111955217 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029789
 protein coding gene Chr6:115748338-115826204 (+)
WSB/EiJ MGP_WSBEiJ_G0030329
 protein coding gene Chr6:117293589-117364792 (+)



Homology
more
  • Human Ortholog
    IFT122, intraflagellar transport 122
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFT122, intraflagellar transport 122
  • Synonyms
    CED, CED1, CFAP80, FAP80, SPG, WDR10, WDR10p, WDR140
  • Links
    NCBI Gene ID: 55764
    neXtProt AC: NX_Q9HBG6
    UniProt: Q9HBG6

  • Chr Location
    3q21.3-q22.1; chr3:129429607-129520510 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IFT122 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 3 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null mutation display embryonic lethality during organogenesis with exencephaly, a ventralized caudal neural tube, preaxial polydactyly, abnormal cilia, and left-right patterning defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    17
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    10
  • cDNA Data
    55
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030323 Ensembl Gene Model | MGI Sequence Detail 73230 C57BL/6J ±  kb
    transcript ENSMUST00000112923 Ensembl | MGI Sequence Detail 3765 Not Applicable  
    polypeptide ENSMUSP00000108545 Ensembl | MGI Sequence Detail 1241 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 55
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141776, MGI:3578193
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 4
      Gene Ontology 17
      Phenotypes 20
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory