Cyp4x1 MGI Mouse Gene Detail - MGI:1932403 - cytochrome P450, family 4, subfamily x, polypeptide 1

Symbol

Cyp4x1
Name

cytochrome P450, family 4, subfamily x, polypeptide 1
Synonyms

Cyp4a28-ps

Feature Type

protein coding gene
IDs

MGI:1932403
NCBI Gene: 81906
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:114963518-114991276 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 52.76 cM
Mapping Data

1 experiment

SNPs within 2kb

808 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932403	protein coding gene	Chr4:114963518-114991478 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028596	protein coding gene	Chr4:115876773-115904162 (-)
A/J	MGP_AJ_G0028558	protein coding gene	Chr4:111469441-111494741 (-)
AKR/J	MGP_AKRJ_G0028506	protein coding gene	Chr4:113763830-113788855 (-)
BALB/cJ	MGP_BALBcJ_G0028578	protein coding gene	Chr4:112099513-112126551 (-)
C3H/HeJ	MGP_C3HHeJ_G0028292	protein coding gene	Chr4:115382154-115407413 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029022	protein coding gene	Chr4:120359747-120395082 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026306	protein coding gene	Chr4:105554158-105581649 (-)
CAST/EiJ	MGP_CASTEiJ_G0027729	protein coding gene	Chr4:112800543-112828605 (-)
CBA/J	MGP_CBAJ_G0028260	protein coding gene	Chr4:123484557-123511967 (-)
DBA/2J	MGP_DBA2J_G0028409	protein coding gene	Chr4:112098942-112127323 (-)
FVB/NJ	MGP_FVBNJ_G0028377	protein coding gene	Chr4:110572062-110597925 (-)
LP/J	MGP_LPJ_G0028510	protein coding gene	Chr4:116086726-116113805 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028402	protein coding gene	Chr4:128618182-128653095 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029058	protein coding gene	Chr4:115012014-115040737 (-)
PWK/PhJ	MGP_PWKPhJ_G0027454	protein coding gene	Chr4:108897913-108924427 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027278	protein coding gene	Chr4:111410347-111433840 (-)
WSB/EiJ	MGP_WSBEiJ_G0027807	protein coding gene	Chr4:114794449-114820326 (-)

Human Ortholog

CYP4X1, cytochrome P450 family 4 subfamily X member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYP4X1, cytochrome P450 family 4 subfamily X member 1
Synonyms

CYPIVX1
Links

HGNC:20244

NCBI Gene ID: 260293

neXtProt AC: NX_Q8N118

UniProt: Q8N118
Chr Location

1p33; chr1:46961364-47055432 (+) GRCh38

MGI Vertebrate Homology

Cyp4x1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CYP4X1
Gene Tree

Cyp4x1

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

1
Targeted

6
Genomic Mutations

4 involving Cyp4x1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit a mildly obese phenotype.

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All GO Annotations

6
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

787
Tissues

46
cDNA Data

6
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS18488.1

Ensembl

ENSMUSG00000047155 (Evidence)
NCBI Gene

81906

			Length	Strain/Species	Flank
genomic	81906	NCBI Gene Model \| MGI Sequence Detail	27759	C57BL/6J	± kb
transcript	NM_001003947	RefSeq \| MGI Sequence Detail	3987	C57BL/6
polypeptide	Q6A152	UniProt \| EBI \| MGI Sequence Detail	507	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006145 cytochrome P450 4X1

(term hierarchy)
EC

1.14.14.-
InterPro Domains

IPR001128 Cytochrome P450

IPR017972 Cytochrome P450, conserved site

IPR002401 Cytochrome P450, E-class, group I

IPR050196 Cytochrome P450 Monooxygenases

IPR036396 Cytochrome P450 superfamily

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 2

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MGI:2449779

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 13
Earliest

J:68016 Gottgens B, et al., Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences. Genome Res. 2001 Jan;11(1):87-97
Latest

J:254435 Kharkwal H, et al., Generation and phenotypic characterisation of a cytochrome P450 4x1 knockout mouse. PLoS One. 2017;12(12):e0187959

TSS for Cyp4x1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr42827	Chr4:114991301-114991318 (-)	-34 bp
Tssr42826	Chr4:114991260-114991281 (-)	5 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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