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Tmem108 Gene Detail
Summary
  • Symbol
    Tmem108
  • Name
    transmembrane protein 108
  • Synonyms
    B130017P16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932411
    NCBI Gene: 81907
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:103360146-103639036 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 55.47 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9271 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932411
 protein coding gene Chr9:103360135-103639099 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035201
 protein coding gene Chr9:105108770-105392215 (-)
A/J MGP_AJ_G0035181
 protein coding gene Chr9:101327267-101605827 (-)
AKR/J MGP_AKRJ_G0035113
 protein coding gene Chr9:103841385-104125505 (-)
BALB/cJ MGP_BALBcJ_G0035174
 protein coding gene Chr9:101035673-101316226 (-)
C3H/HeJ MGP_C3HHeJ_G0034884
 protein coding gene Chr9:104229179-104512320 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035694
 protein coding gene Chr9:108033259-108325885 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032592
 protein coding gene Chr9:98907271-99181476 (-)
CAST/EiJ MGP_CASTEiJ_G0034196
 protein coding gene Chr9:104084287-104379070 (-)
CBA/J MGP_CBAJ_G0034853
 protein coding gene Chr9:111792087-112084360 (-)
DBA/2J MGP_DBA2J_G0035014
 protein coding gene Chr9:100815050-101097454 (-)
FVB/NJ MGP_FVBNJ_G0034962
 protein coding gene Chr9:99619531-99902385 (-)
LP/J MGP_LPJ_G0035090
 protein coding gene Chr9:105316923-105604396 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035001
 protein coding gene Chr9:113585336-113873188 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035716
 protein coding gene Chr9:104083223-104371671 (-)
PWK/PhJ MGP_PWKPhJ_G0033903
 protein coding gene Chr9:101077206-101365056 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033738
 protein coding gene Chr9:104133842-104427155 (-)
WSB/EiJ MGP_WSBEiJ_G0034316
 protein coding gene Chr9:103968526-104254711 (-)



Homology
more
  • Human Ortholog
    TMEM108, transmembrane protein 108
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM108, transmembrane protein 108
  • Synonyms
    CT124, RTLN
  • Links
    NCBI Gene ID: 66000
    neXtProt AC: NX_Q6UXF1
    UniProt: Q6UXF1

  • Chr Location
    3q22.1; chr3:133038391-133397775 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with drastically reduced expression exhibit decreased excitatory postsynaptic currents of dentate gyrate granule neurons, impaired sensorimotor gating, and behavioral deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    6
  • cDNA Data
    30
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042757 Ensembl Gene Model | MGI Sequence Detail 278891 C57BL/6J ±  kb
    transcript ENSMUST00000049452 Ensembl | MGI Sequence Detail 3574 Not Applicable  
    polypeptide ENSMUSP00000046021 Ensembl | MGI Sequence Detail 574 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 31

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2143066
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:67229 Omran H, et al., Human adolescent nephronophthisis: gene locus synteny with polycystic kidney disease in pcy mice. J Am Soc Nephrol. 2001 Jan;12(1):107-13
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory