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Ndst3 Gene Detail
Summary
  • Symbol
    Ndst3
  • Name
    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
  • Synonyms
    4921531K01Rik, 4930511P15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932544
    NCBI Gene: 83398
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:123319815-123484502 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 54.58 cM, cytoband G3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5275 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932544
 protein coding gene Chr3:123319815-123484822 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027851
 protein coding gene Chr3:125836379-126012482 (-)
A/J MGP_AJ_G0027810
 protein coding gene Chr3:121623323-121783036 (-)
AKR/J MGP_AKRJ_G0027775
 protein coding gene Chr3:124727730-124901933 (-)
BALB/cJ MGP_BALBcJ_G0027822
 protein coding gene Chr3:121431261-121590650 (-)
C3H/HeJ MGP_C3HHeJ_G0027552
 protein coding gene Chr3:125121468-125284280 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028267
 protein coding gene Chr3:130396065-130578972 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025604
 protein coding gene Chr3:117040184-117198044 (-)
CAST/EiJ MGP_CASTEiJ_G0027007
 protein coding gene Chr3:124542107-124717312 (-)
CBA/J MGP_CBAJ_G0027527
 protein coding gene Chr3:134795699-134966694 (-)
DBA/2J MGP_DBA2J_G0027668
 protein coding gene Chr3:120753924-120919648 (-)
FVB/NJ MGP_FVBNJ_G0027636
 protein coding gene Chr3:118375568-118542676 (-)
LP/J MGP_LPJ_G0027778
 protein coding gene Chr3:127375508-127552072 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027666
 protein coding gene Chr3:142370813-142546353 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028323
 protein coding gene Chr3:124298772-124468542 (-)
PWK/PhJ MGP_PWKPhJ_G0026733
 protein coding gene Chr3:120499487-120661248 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026557
 protein coding gene Chr3:122407696-122569740 (-)
WSB/EiJ MGP_WSBEiJ_G0027087
 protein coding gene Chr3:125052088-125219527 (-)



Homology
more
  • Human Ortholog
    NDST3, N-deacetylase and N-sulfotransferase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDST3, N-deacetylase and N-sulfotransferase 3
  • Synonyms
    HSST3
  • Links
    NCBI Gene ID: 9348
    neXtProt AC: NX_O95803
    UniProt: O95803

  • Chr Location
    4q26; chr4:118033322-118258634 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit decreased anxiety-related behavior, cholesterol levels and CD8+ T cells due to moderate heparan-sulfate undersulfation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    918
  • Tissues
    154
  • cDNA Data
    10
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027977 Ensembl Gene Model | MGI Sequence Detail 164688 C57BL/6J ±  kb
    transcript ENSMUST00000029602 Ensembl | MGI Sequence Detail 5335 Not Applicable  
    polypeptide ENSMUSP00000029602 Ensembl | MGI Sequence Detail 873 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 10
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918208, MGI:1921948
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory