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Ndst4 Gene Detail
Summary
  • Symbol
    Ndst4
  • Name
    N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
  • Synonyms
    4930439H17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932545
    NCBI Gene: 64580
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:125197725-125522548 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 54.68 cM, cytoband H1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10459 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932545
 protein coding gene Chr3:125197678-125522550 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027855
 protein coding gene Chr3:127784950-128131254 (+)
A/J MGP_AJ_G0027814
 protein coding gene Chr3:123409177-123741470 (+)
AKR/J MGP_AKRJ_G0027779
 protein coding gene Chr3:126611072-126955591 (+)
BALB/cJ MGP_BALBcJ_G0027826
 protein coding gene Chr3:123257799-123589340 (+)
C3H/HeJ MGP_C3HHeJ_G0027556
 protein coding gene Chr3:126973943-127308575 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028271
 protein coding gene Chr3:132420300-132768321 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025608
 protein coding gene Chr3:118730821-119062764 (+)
CAST/EiJ MGP_CASTEiJ_G0027011
 protein coding gene Chr3:126458387-126818535 (+)
CBA/J MGP_CBAJ_G0027531
 protein coding gene Chr3:136832853-137193382 (+)
DBA/2J MGP_DBA2J_G0027672
 protein coding gene Chr3:122645758-122971028 (+)
FVB/NJ MGP_FVBNJ_G0027640
 protein coding gene Chr3:120233650-120564712 (+)
LP/J MGP_LPJ_G0027782
 protein coding gene Chr3:129313052-129651843 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027670
 protein coding gene Chr3:144700603-145116815 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028327
 protein coding gene Chr3:126242469-126600743 (+)
PWK/PhJ MGP_PWKPhJ_G0026737
 protein coding gene Chr3:122370008-122709204 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026561
 protein coding gene Chr3:124301270-124640521 (+)
WSB/EiJ MGP_WSBEiJ_G0027091
 protein coding gene Chr3:126937469-127284602 (+)



Homology
more
  • Human Ortholog
    NDST4, N-deacetylase and N-sulfotransferase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDST4, N-deacetylase and N-sulfotransferase 4
  • Synonyms
    NDST-4, N-HSST, N-HSST 4, NHSST4
  • Links
    NCBI Gene ID: 64579
    neXtProt AC: NX_Q9H3R1
    UniProt: Q9H3R1

  • Chr Location
    4q26; chr4:114827763-115113876 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a phenotype restricted to the colonic epithelium that includes an increased number of colon goblet cells, a decreased number of colonocytes, and increased apoptosis of colonic epithelial cells in the proximal colon.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    888
  • Tissues
    128
  • cDNA Data
    8
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027971 Ensembl Gene Model | MGI Sequence Detail 324824 C57BL/6J ±  kb
    transcript ENSMUST00000173932 Ensembl | MGI Sequence Detail 7417 Not Applicable  
    polypeptide ENSMUSP00000133341 Ensembl | MGI Sequence Detail 872 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 9
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1921219
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory