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Noc3l Gene Detail
Summary
  • Symbol
    Noc3l
  • Name
    NOC3 like DNA replication regulator
  • Synonyms
    Fad24
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932610
    NCBI Gene: 57753
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:38776572-38807681 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 33.42 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1128 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932610
 protein coding gene Chr19:38776565-38808754 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025094
 protein coding gene Chr19:37864519-37907642 (-)
A/J MGP_AJ_G0025070
 protein coding gene Chr19:36035827-36070180 (-)
AKR/J MGP_AKRJ_G0025038
 protein coding gene Chr19:37225341-37258665 (-)
BALB/cJ MGP_BALBcJ_G0025068
 protein coding gene Chr19:36136056-36167715 (-)
C3H/HeJ MGP_C3HHeJ_G0024827
 protein coding gene Chr19:37345447-37378744 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025509
 protein coding gene Chr19:38948786-38982361 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022928
 protein coding gene Chr19:35357987-35388440 (-)
CAST/EiJ MGP_CASTEiJ_G0024294
 protein coding gene Chr19:37202404-37235554 (-)
CBA/J MGP_CBAJ_G0024804
 protein coding gene Chr19:40781528-40817186 (-)
DBA/2J MGP_DBA2J_G0024936
 protein coding gene Chr19:35871755-35903069 (-)
FVB/NJ MGP_FVBNJ_G0024897
 protein coding gene Chr19:35702053-35734875 (-)
LP/J MGP_LPJ_G0025022
 protein coding gene Chr19:37956142-37988911 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024928
 protein coding gene Chr19:40514301-40546792 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025567
 protein coding gene Chr19:37355259-37390243 (-)
PWK/PhJ MGP_PWKPhJ_G0024046
 protein coding gene Chr19:35747485-35779424 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023846
 protein coding gene Chr19:36192523-36224892 (-)
WSB/EiJ MGP_WSBEiJ_G0024361
 protein coding gene Chr19:37445770-37478598 (-)



Homology
more
  • Human Ortholog
    NOC3L, NOC3 like DNA replication regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOC3L, NOC3 like DNA replication regulator
  • Synonyms
    AD24, C10orf117, FAD24
  • Links
    NCBI Gene ID: 64318
    neXtProt AC: NX_Q8WTT2
    UniProt: Q8WTT2

  • Chr Location
    10q23.33; chr10:94314907-94362959 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality, fail to form blastocele and arrest at the morula stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    25
  • cDNA Data
    66
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024999 Ensembl Gene Model | MGI Sequence Detail 31110 C57BL/6J ±  kb
    transcript ENSMUST00000025963 Ensembl | MGI Sequence Detail 3977 Not Applicable  
    polypeptide ENSMUSP00000025963 Ensembl | MGI Sequence Detail 807 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 66
      Primer pair 1
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:66491 Tidhar A, et al., A novel transgenic marker for migrating limb muscle precursors and for vascular smooth muscle cells. Dev Dyn. 2001 Jan;220(1):60-73
    • Latest
      J:262823 Kasowitz SD, et al., Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet. 2018 May;14(5):e1007412
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory