Ndel1 MGI Mouse Gene Detail - MGI:1932915 - nudE neurodevelopment protein 1 like 1

Symbol

Ndel1
Name

nudE neurodevelopment protein 1 like 1
Synonyms

2600006O07Rik, mNudel

Feature Type

protein coding gene
IDs

MGI:1932915
NCBI Gene: 83431
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:68712260-68743961 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.09 cM
Mapping Data

2 experiments

SNPs within 2kb

747 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932915	protein coding gene	Chr11:68712260-68762684 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018505	protein coding gene	Chr11:69194757-69253067 (-)
A/J	MGP_AJ_G0018474	protein coding gene	Chr11:66606664-66659038 (-)
AKR/J	MGP_AKRJ_G0018443	protein coding gene	Chr11:68591903-68645497 (-)
BALB/cJ	MGP_BALBcJ_G0018445	protein coding gene	Chr11:66892434-66952984 (-)
C3H/HeJ	MGP_C3HHeJ_G0018258	protein coding gene	Chr11:68612116-68667822 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018897	protein coding gene	Chr11:71295026-71361239 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016541	protein coding gene	Chr11:63549856-63596114 (-)
CAST/EiJ	MGP_CASTEiJ_G0017814	protein coding gene	Chr11:68842822-68903349 (-)
CBA/J	MGP_CBAJ_G0018232	protein coding gene	Chr11:74459134-74521152 (-)
DBA/2J	MGP_DBA2J_G0018341	protein coding gene	Chr11:66203474-66253645 (-)
FVB/NJ	MGP_FVBNJ_G0018331	protein coding gene	Chr11:65825737-65877109 (-)
LP/J	MGP_LPJ_G0018412	protein coding gene	Chr11:69771723-69831740 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018354	protein coding gene	Chr11:75149740-75210270 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018938	protein coding gene	Chr11:68836150-68893082 (-)
PWK/PhJ	MGP_PWKPhJ_G0017589	protein coding gene	Chr11:66827781-66881483 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017377	protein coding gene	Chr11:68669224-68722621 (-)
WSB/EiJ	MGP_WSBEiJ_G0017867	protein coding gene	Chr11:68471978-68530167 (-)

Human Ortholog

NDEL1, nudE neurodevelopment protein 1 like 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NDEL1, nudE neurodevelopment protein 1 like 1
Synonyms

EOPA, MITAP1, NDE1L1, NDE2, NUDEL
Links

HGNC:17620

NCBI Gene ID: 81565

neXtProt AC: NX_Q9GZM8

UniProt: Q9GZM8
Chr Location

17p13.1; chr17:8413131-8490411 (+) GRCh38

MGI Vertebrate Homology

Ndel1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NDEL1
Gene Tree

Ndel1

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Phenotype Summary

9 phenotypes from 4 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

13
Targeted

8
Genomic Mutations

1 involving Ndel1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene causes peri-implantation lethality. Blastocysts fail to grow in culture and exhibit inner cell mass degeneration. Compound heterozygous mice carrying one null and one hypomorphic allele show mild neuronal migration defects.

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All GO Annotations

86
GO References

25

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

949
Tissues

149
cDNA Data

13
Literature Summary

20

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NDEL1

Xenbase ndel1

ZFIN ndel1a, ndel1b

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All Sequences

61
RefSeq

8
UniProt

1
CCDS

CCDS24870.1

Ensembl

ENSMUSG00000018736 (Evidence)
NCBI Gene

83431

			Length	Strain/Species	Flank
genomic	83431	NCBI Gene Model \| MGI Sequence Detail	31702	C57BL/6J	± kb
transcript	NM_001363304	RefSeq \| MGI Sequence Detail	2417	C57BL/6
polypeptide	Q9ERR1	UniProt \| EBI \| MGI Sequence Detail	345	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011052 nuclear distribution protein nudE-like 1

(term hierarchy)
PDB

5YI4, 6KZJ
InterPro Domains

IPR006964 NUDE domain

IPR033494 NUDE family

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All nucleic 16

cDNA 13

Primer pair 2

Other 1

Microarray probesets 7

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MGI:1919693

Summaries

All 87

Developmental Gene Expression 20

Gene Ontology 25

Phenotypes 27
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ndel1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108594	Chr11:68745110-68745125 (-)	-1,157 bp
Tssr3535	Chr11:68744976-68745005 (-)	-1,030 bp
Tssr108593	Chr11:68744879-68744882 (-)	-920 bp
Tssr108592	Chr11:68743945-68743966 (-)	5 bp
Tssr108591	Chr11:68743845-68743927 (-)	75 bp
Tssr108590	Chr11:68743809-68743829 (-)	142 bp
Tssr108589	Chr11:68729571-68729578 (-)	14,386 bp
Tssr108588	Chr11:68716144-68716146 (-)	27,816 bp
Tssr108587	Chr11:68715897-68715900 (-)	28,062 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24