Mettl27 Gene Detail

Summary

• Symbol
  Mettl27
• Name
  methyltransferase like 27
• Synonyms
  MGC:8159, Wbscr27

• Feature Type
  protein coding gene
• IDs
  MGI:1933146
  NCBI Gene: 79565
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr5:134961222-134971491 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, 74.89 cM
• Mapping Data
  4 experiments

Strain
Comparison

• SNPs within 2kb
  436 from dbSNP Build 142
• Strain Annotations
  17

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933146	protein coding gene	Chr5:134961158-134971491 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030166	protein coding gene	Chr5:139401076-139411644 (+)
A/J	MGP_AJ_G0030134	protein coding gene	Chr5:133455070-133464908 (+)
AKR/J	MGP_AKRJ_G0030067	protein coding gene	Chr5:137796071-137805856 (+)
BALB/cJ	MGP_BALBcJ_G0030144	protein coding gene	Chr5:134810477-134820812 (+)
C3H/HeJ	MGP_C3HHeJ_G0029860	protein coding gene	Chr5:138352075-138363318 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030597	protein coding gene	Chr5:144635539-144645766 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0029269	protein coding gene	Chr5:137777524-137787234 (+)
CBA/J	MGP_CBAJ_G0029830	protein coding gene	Chr5:150285534-150295916 (+)
DBA/2J	MGP_DBA2J_G0029981	protein coding gene	Chr5:133351550-133361554 (+)
FVB/NJ	MGP_FVBNJ_G0029936	protein coding gene	Chr5:132483725-132494001 (+)
LP/J	MGP_LPJ_G0030069	protein coding gene	Chr5:139860350-139871914 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029968	protein coding gene	Chr5:153307713-153318100 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030637	protein coding gene	Chr5:137529220-137540844 (+)
PWK/PhJ	MGP_PWKPhJ_G0028984	protein coding gene	Chr5:132395292-132405357 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028819	protein coding gene	Chr5:135099977-135111000 (+)
WSB/EiJ	MGP_WSBEiJ_G0029343	protein coding gene	Chr5:138284966-138295746 (+)

Homology

• Human Ortholog
  METTL27, methyltransferase like 27

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  METTL27, methyltransferase like 27
  
• Synonyms
  WBSCR27
• Links
  HGNC:19068

  NCBI Gene ID: 155368

  neXtProt AC: NX_Q8N6F8

  UniProt: Q8N6F8

  
  
• Chr Location
  7q11.23; chr7:73834590-73842516 (-)  GRCh38

---

• MGI Vertebrate Homology
  Mettl27 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: METTL27
• Gene Tree
  Mettl27
  

Human Diseases

• References
  2 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  15 phenotype references
  

• All Mutations and Alleles
  6
• Endonuclease-mediated
  1
• Gene trapped
  2
• Targeted
  3
• Genomic Mutations
  2 involving Mettl27
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  12 strains or lines available

Expression

• Assay Results
  706
• cDNA Data
  6

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase mettl27
  ZFIN mettl27

Sequences &
Gene Models

• All Sequences
  86
• RefSeq
  30
• UniProt
  7
• CCDS
  CCDS19727.1, CCDS84970.1

• Ensembl
  ENSMUSG00000040557 (Evidence)
• NCBI Gene
  79565

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000040557	Ensembl Gene Model | MGI Sequence Detail	10270	C57BL/6J
transcript	ENSMUST00000047196	Ensembl | MGI Sequence Detail	2808	Not Applicable
polypeptide	ENSMUSP00000039080	Ensembl | MGI Sequence Detail	238	Not Applicable

Protein
Information

• UniProt
  7 Sequences
• PDB
  7QCB, 7QCC
• InterPro Domains
  IPR041698 Methyltransferase domain 25
  IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

Molecular
Reagents

• All nucleic 7

  Genomic 1

  cDNA 6

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:2141200, MGI:5883608

References

• Summaries
  All 35

  Diseases 2

  Phenotypes 15
• Earliest
  J:73830 DeSilva U, et al., Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. Genome Res. 2002 Jan;12(1):3-15
• Latest
  J:337436 Abdalla N, et al., Dysfunctional Mitochondria in the Cardiac Fibers of a Williams-Beuren Syndrome Mouse Model. Int J Mol Sci. 2023 Jun 13;24(12)

TSS for Mettl27:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49105	Chr5:134961205-134961236 (+)	-1 bp
Tssr49106	Chr5:134961249-134961276 (+)	41 bp
Tssr1660	Chr5:134967306-134967307 (+)	6,085 bp