Arl4d MGI Mouse Gene Detail - MGI:1933155 - ADP-ribosylation factor-like 4D

Symbol

Arl4d
Name

ADP-ribosylation factor-like 4D
Synonyms

1110036H21Rik, Arf4l, Arfl4, Arl5

Feature Type

protein coding gene
IDs

MGI:1933155
NCBI Gene: 80981
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:101556367-101558658 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 65.48 cM
Mapping Data

3 experiments

SNPs within 2kb

169 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933155	protein coding gene	Chr11:101556367-101558658 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019210	protein coding gene	Chr11:104575035-104577328 (+)
A/J	MGP_AJ_G0019178	protein coding gene	Chr11:100170320-100172614 (+)
AKR/J	MGP_AKRJ_G0019147	protein coding gene	Chr11:103281076-103285051 (+)
BALB/cJ	MGP_BALBcJ_G0019152	protein coding gene	Chr11:100650818-100653109 (+)
C3H/HeJ	MGP_C3HHeJ_G0018961	protein coding gene	Chr11:103467430-103470443 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019601	protein coding gene	Chr11:107837412-107839703 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017227	protein coding gene	Chr11:97596454-97598738 (+)
CAST/EiJ	MGP_CASTEiJ_G0018515	protein coding gene	Chr11:104425367-104432689 (+)
CBA/J	MGP_CBAJ_G0018930	protein coding gene	Chr11:112269132-112271423 (+)
DBA/2J	MGP_DBA2J_G0019042	protein coding gene	Chr11:99686201-99688593 (+)
FVB/NJ	MGP_FVBNJ_G0019032	protein coding gene	Chr11:99219586-99221877 (+)
LP/J	MGP_LPJ_G0019111	protein coding gene	Chr11:105099459-105101751 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019063	protein coding gene	Chr11:111839832-111842118 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019639	protein coding gene	Chr11:103615345-103617638 (+)
PWK/PhJ	MGP_PWKPhJ_G0018278	protein coding gene	Chr11:100741888-100744209 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018070	protein coding gene	Chr11:103339968-103342170 (+)
WSB/EiJ	MGP_WSBEiJ_G0018564	protein coding gene	Chr11:103607696-103609985 (+)

Human Ortholog

ARL4D, ARF like GTPase 4D

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARL4D, ARF like GTPase 4D
Synonyms

ARF4L
Links

HGNC:656

NCBI Gene ID: 379

neXtProt AC: NX_P49703

UniProt: P49703
Chr Location

17q21.31; chr17:43398993-43401137 (+) GRCh38

MGI Vertebrate Homology

Arl4d stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARL4D
Gene Tree

Arl4d

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

1
Targeted

3
Genomic Mutations

1 involving Arl4d
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

17
cDNA Data

30
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS36336.1

Ensembl

ENSMUSG00000034936 (Evidence)
NCBI Gene

80981

			Length	Strain/Species	Flank
genomic	80981	NCBI Gene Model \| MGI Sequence Detail	2292	C57BL/6J	± kb
transcript	NM_025404	RefSeq \| MGI Sequence Detail	1397	C57BL/6
polypeptide	Q99PE9	UniProt \| EBI \| MGI Sequence Detail	201	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004287 ADP-ribosylation factor-like protein 4D

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR006689 Small GTPase superfamily, ARF/SAR type

IPR024156 Small GTPase superfamily, ARF type

IPR005225 Small GTP-binding protein domain

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All nucleic 31

cDNA 30

Primer pair 1

Microarray probesets 4

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MGI:1913432, MGI:2144528

Summaries

All 51

Developmental Gene Expression 6

Gene Ontology 7

Phenotypes 15
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arl4d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105156	Chr11:101556380-101556398 (+)	22 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24