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Trim2 Gene Detail
Summary
  • Symbol
    Trim2
  • Name
    tripartite motif-containing 2
  • Synonyms
    narf, neural activity-related ring finger protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933163
    NCBI Gene: 80890
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:84067746-84214184 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 37.48 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4421 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933163
 protein coding gene Chr3:84067746-84215659 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027340
 protein coding gene Chr3:84059594-84211576 (-)
A/J MGP_AJ_G0027304
 protein coding gene Chr3:81271373-81420790 (-)
AKR/J MGP_AKRJ_G0027270
 protein coding gene Chr3:83187716-83337490 (-)
BALB/cJ MGP_BALBcJ_G0027313
 protein coding gene Chr3:81343823-81491505 (-)
C3H/HeJ MGP_C3HHeJ_G0027057
 protein coding gene Chr3:83502826-83652272 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027759
 protein coding gene Chr3:87197240-87351427 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025112
 protein coding gene Chr3:76943838-77086880 (-)
CAST/EiJ MGP_CASTEiJ_G0026504
 protein coding gene Chr3:83673014-83826855 (-)
CBA/J MGP_CBAJ_G0027032
 protein coding gene Chr3:90126889-90288896 (-)
DBA/2J MGP_DBA2J_G0027168
 protein coding gene Chr3:80792413-80938240 (-)
FVB/NJ MGP_FVBNJ_G0027136
 protein coding gene Chr3:79074406-79222953 (-)
LP/J MGP_LPJ_G0027276
 protein coding gene Chr3:85033801-85189125 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027155
 protein coding gene Chr3:96494275-96651880 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027817
 protein coding gene Chr3:82986891-83136720 (-)
PWK/PhJ MGP_PWKPhJ_G0026238
 protein coding gene Chr3:80557204-80709858 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026054
 protein coding gene Chr3:82161046-82313807 (-)
WSB/EiJ MGP_WSBEiJ_G0026582
 protein coding gene Chr3:83340818-83498090 (-)



Homology
more
  • Human Ortholog
    TRIM2, tripartite motif containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM2, tripartite motif containing 2
  • Synonyms
    CMT2R, RNF86
  • Links
    NCBI Gene ID: 23321
    neXtProt AC: NX_Q9C040
    UniProt: Q9C040

  • Chr Location
    4q31.3; chr4:153152163-153339319 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TRIM2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit tremors, ataxia and seizures associated with neurodegeneration of Purkinje cells, deep cerebellar nuclei and retinal ganglion cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1157
  • Tissues
    151
  • cDNA Data
    20
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027993 Ensembl Gene Model | MGI Sequence Detail 146439 C57BL/6J ±  kb
    transcript ENSMUST00000054990 Ensembl | MGI Sequence Detail 3816 Not Applicable  
    polypeptide ENSMUSP00000049902 Ensembl | MGI Sequence Detail 770 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 23
      Primer pair 1
      Other 2

      Microarray probesets 12
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:68594 Ohkawa N, et al., Molecular cloning and characterization of neural activity-related RING finger protein (NARF): a new member of the RBCC family is a candidate for the partner of myosin V. J Neurochem. 2001 Jul;78(1):75-87
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory