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Plagl2 Gene Detail
Summary
  • Symbol
    Plagl2
  • Name
    pleiomorphic adenoma gene-like 2
  • Synonyms
    mKIAA0198
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933165
    NCBI Gene: 54711
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:153069689-153083278 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.41 cM, cytoband H2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    220 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933165
 protein coding gene Chr2:153069679-153083346 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026689
 protein coding gene Chr2:157843840-157858686 (-)
A/J MGP_AJ_G0026655
 protein coding gene Chr2:151529754-151543455 (-)
AKR/J MGP_AKRJ_G0026626
 protein coding gene Chr2:155960492-155974160 (-)
BALB/cJ MGP_BALBcJ_G0026665
 protein coding gene Chr2:151841683-151856102 (-)
C3H/HeJ MGP_C3HHeJ_G0026407
 protein coding gene Chr2:156333653-156347315 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027114
 protein coding gene Chr2:162432037-162448591 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024485
 protein coding gene Chr2:145109969-145123469 (-)
CAST/EiJ MGP_CASTEiJ_G0025869
 protein coding gene Chr2:156588739-156602416 (-)
CBA/J MGP_CBAJ_G0026386
 protein coding gene Chr2:168404468-168426263 (-)
DBA/2J MGP_DBA2J_G0026522
 protein coding gene Chr2:150739714-150753195 (-)
FVB/NJ MGP_FVBNJ_G0026488
 protein coding gene Chr2:149208266-149221991 (-)
LP/J MGP_LPJ_G0026626
 protein coding gene Chr2:157991953-158008281 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026509
 protein coding gene Chr2:172448758-172466020 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027169
 protein coding gene Chr2:155859892-155875831 (-)
PWK/PhJ MGP_PWKPhJ_G0025603
 protein coding gene Chr2:150274415-150288062 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025406
 protein coding gene Chr2:154690646-154704646 (-)
WSB/EiJ MGP_WSBEiJ_G0025939
 protein coding gene Chr2:156755419-156769092 (-)



Homology
more
  • Human Ortholog
    PLAGL2, PLAG1 like zinc finger 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLAGL2, PLAG1 like zinc finger 2
  • Synonyms
    ZNF900
  • Links
    NCBI Gene ID: 5326
    neXtProt AC: NX_Q9UPG8
    UniProt: Q9UPG8

  • Chr Location
    20q11.21; chr20:32192504-32207743 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal death due to a failure to absorb lipids in the intestine and other organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    931
  • Tissues
    166
  • cDNA Data
    88
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54711 NCBI Gene Model | MGI Sequence Detail 13590 C57BL/6J ±  kb
    transcript NM_018807 RefSeq | MGI Sequence Detail 5407 C57BL/6  
    polypeptide NP_061277 RefSeq | MGI Sequence Detail 496 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    Molecular
    Reagents
    less
    • All nucleic 94
      cDNA 88
      Primer pair 5
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2139171, MGI:2139391
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 14
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory