Ctps2 MGI Mouse Gene Detail - MGI:1933185 - cytidine 5'-triphosphate synthase 2

Symbol

Ctps2
Name

cytidine 5'-triphosphate synthase 2
Synonyms

A830031M15Rik, CTPsH

Feature Type

protein coding gene
IDs

MGI:1933185
NCBI Gene: 55936
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

ChrX:161684234-161815504 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 75.09 cM, cytoband F5
Mapping Data

3 experiments

SNPs within 2kb

3136 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933185	protein coding gene	ChrX:161684234-161817537 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036243	protein coding gene	ChrX:160929357-161065593 (+)
A/J	MGP_AJ_G0036213	protein coding gene	ChrX:160136735-160270021 (+)
AKR/J	MGP_AKRJ_G0036141	protein coding gene	ChrX:165255582-165388870 (+)
BALB/cJ	MGP_BALBcJ_G0036206	protein coding gene	ChrX:158142121-158269173 (+)
C3H/HeJ	MGP_C3HHeJ_G0035912	protein coding gene	ChrX:161292599-161431760 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036728	protein coding gene	ChrX:165668281-165802946 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033550	protein coding gene	ChrX:151222021-151353844 (+)
CAST/EiJ	MGP_CASTEiJ_G0035201	protein coding gene	ChrX:140275701-140408233 (+)
CBA/J	MGP_CBAJ_G0035887	protein coding gene	ChrX:170426279-170607243 (+)
DBA/2J	MGP_DBA2J_G0036053	protein coding gene	ChrX:159043458-159177802 (+)
FVB/NJ	MGP_FVBNJ_G0035984	protein coding gene	ChrX:158178321-158313834 (+)
LP/J	MGP_LPJ_G0036138	protein coding gene	ChrX:162106756-162240060 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0036016	protein coding gene	ChrX:179116635-179262058 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036769	protein coding gene	ChrX:160433626-160565922 (+)
PWK/PhJ	MGP_PWKPhJ_G0034899	protein coding gene	ChrX:137084378-137215655 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034720	protein coding gene	ChrX:140744331-140875533 (+)
WSB/EiJ	MGP_WSBEiJ_G0035336	protein coding gene	ChrX:158403678-158535416 (+)

Human Ortholog

CTPS2, CTP synthase 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTPS2, CTP synthase 2
Synonyms

GATD5B
Links

HGNC:2520

NCBI Gene ID: 56474

neXtProt AC: NX_Q9NRF8

UniProt: Q9NRF8
Chr Location

Xp22.2; chrX:16587999-16712936 (-) GRCh38

MGI Vertebrate Homology

Ctps2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CTPS2
Gene Tree

Ctps2

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Phenotype Summary

2 phenotypes from 3 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
4 images
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

43
Endonuclease-mediated

5
Gene trapped

32
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male chimeras hemizygous for a gene trapped allele appear normal at E9.5.

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All GO Annotations

13
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

829
Tissues

123
cDNA Data

99
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctps2

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All Sequences

91
RefSeq

25
UniProt

2
CCDS

CCDS41202.1, CCDS53240.1

Ensembl

ENSMUSG00000031360 (Evidence)
NCBI Gene

55936

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031360	Ensembl Gene Model \| MGI Sequence Detail	131271	C57BL/6J	± kb
transcript	ENSMUST00000112301	Ensembl \| MGI Sequence Detail	3099	Not Applicable
polypeptide	ENSMUSP00000107920	Ensembl \| MGI Sequence Detail	586	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006016 CTP synthase 2

(term hierarchy)
PDB

7MIU, 7MIV
EC

6.3.4.2
InterPro Domains

IPR029062 Class I glutamine amidotransferase-like

IPR004468 CTP synthase

IPR033828 CTP synthase GATase domain

IPR017456 CTP synthase, N-terminal

IPR017926 Glutamine amidotransferase

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 99

cDNA 99

Microarray probesets 8

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MGI:2147879

Summaries

All 52

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 18
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:348981 Soudais C, et al., Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice. Nat Commun. 2024 Mar 4;15(1):1982

TSS for Ctps2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr162588	ChrX:161684222-161684257 (+)	6 bp
Tssr162589	ChrX:161684563-161684673 (+)	384 bp
Tssr162590	ChrX:161684675-161684689 (+)	448 bp
Tssr162591	ChrX:161684690-161684729 (+)	476 bp
Tssr162592	ChrX:161684758-161684769 (+)	530 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24