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Nxf2 Gene Detail
Summary
  • Symbol
    Nxf2
  • Name
    nuclear RNA export factor 2
  • Synonyms
    4930455N06Rik, Nxf-b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933192
    NCBI Gene: 83454
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:133845275-133865503 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 56.31 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    449 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933192
 protein coding gene ChrX:133845275-133865503 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036079
 protein coding gene ChrX:132145477-132166108 (-)
A/J MGP_AJ_G0036058
 protein coding gene ChrX:131598328-131619180 (-)
AKR/J MGP_AKRJ_G0035980
 protein coding gene ChrX:135798451-135819662 (-)
BALB/cJ MGP_BALBcJ_G0036051
 protein coding gene ChrX:130008637-130028611 (-)
C3H/HeJ MGP_C3HHeJ_G0035755
 protein coding gene ChrX:132229256-132250725 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036573
 protein coding gene ChrX:136031441-136054380 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033402
 protein coding gene ChrX:123729610-123749014 (-)
CAST/EiJ MGP_CASTEiJ_G0035043
 protein coding gene ChrX:113089465-113111820 (-)
CBA/J MGP_CBAJ_G0035732
 protein coding gene ChrX:140137858-140163400 (-)
DBA/2J MGP_DBA2J_G0035887
 protein coding gene ChrX:130874167-130894943 (-)
FVB/NJ MGP_FVBNJ_G0035828
 protein coding gene ChrX:130203211-130225019 (-)
LP/J MGP_LPJ_G0035980
 protein coding gene ChrX:133053073-133074285 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035857
 protein coding gene ChrX:147507576-147535872 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036604
 protein coding gene ChrX:131586335-131607255 (-)
PWK/PhJ MGP_PWKPhJ_G0034735
 protein coding gene ChrX:110032068-110052789 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034566
 protein coding gene ChrX:113759958-113782511 (-)
WSB/EiJ MGP_WSBEiJ_G0035181
 protein coding gene ChrX:129954150-129976173 (-)



Homology
more
  • Human Ortholog
    NXF2, nuclear RNA export factor 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NXF2, nuclear RNA export factor 2
  • Synonyms
    CT39, TAPL-2, TCP11X2
  • Links
    NCBI Gene ID: 56001
    neXtProt AC: NX_Q9GZY0
    UniProt: Q9GZY0

  • Chr Location
    Xq22.1; chrX:102247167-102326722 (+)  GRCh38
  • Human Ortholog
    NXF2B, nuclear RNA export factor 2B
  • Synonyms
    bA353J17.1, TCP11X2
  • Links
    NCBI Gene ID: 728343
    neXtProt AC: NX_Q9GZY0
    UniProt: Q9GZY0

  • Chr Location
    Xq22.1; chrX:102360395-102440008 (-)  GRCh38
  • Human Ortholog
    NXF5, nuclear RNA export factor 5
  • Links
    NCBI Gene ID: 55998
    neXtProt AC: NX_Q9H1B4
    UniProt: Q9H1B4

  • Chr Location
    Xq22.1; chrX:101832112-101857577 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice heterogyzous for the null allele exhibit reduced fertility associated with abnormal meiosis or reduced spermatogonia proliferation depending on strain background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    46
  • cDNA Data
    9
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83454 NCBI Gene Model | MGI Sequence Detail 20229 C57BL/6J ±  kb
    transcript NM_001289735 RefSeq | MGI Sequence Detail 2395 Not Specified  
    polypeptide NP_001276664 RefSeq | MGI Sequence Detail 691 Not Specified  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR032710 NTF2-like domain superfamily
      IPR030217 Nuclear RNA export factor
      IPR015245 Nuclear RNA export factor Tap, RNA-binding domain
      IPR002075 Nuclear transport factor 2 domain
      IPR018222 Nuclear transport factor 2, eukaryote
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR005637 TAP C-terminal (TAP-C) domain
      IPR009060 UBA-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 9
      Primer pair 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1922121
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:210663 Zhou J, et al., Respiratory failure, cleft palate and epilepsy in the mouse model of human Xq22.1 deletion syndrome. Hum Mol Genet. 2014 Jul 15;23(14):3823-9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory