Tm6sf2 MGI Mouse Gene Detail - MGI:1933210 - transmembrane 6 superfamily member 2

Symbol

Tm6sf2
Name

transmembrane 6 superfamily member 2

Feature Type

protein coding gene
IDs

MGI:1933210
NCBI Gene: 107770
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:70525574-70532716 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.15 cM
Mapping Data

1 experiment

SNPs within 2kb

217 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933210	protein coding gene	Chr8:70525574-70532716 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033687	protein coding gene	Chr8:70320244-70327345 (+)
A/J	MGP_AJ_G0033670	protein coding gene	Chr8:67459369-67466524 (+)
AKR/J	MGP_AKRJ_G0033595	protein coding gene	Chr8:69379992-69387106 (+)
BALB/cJ	MGP_BALBcJ_G0033666	protein coding gene	Chr8:67689695-67696792 (+)
C3H/HeJ	MGP_C3HHeJ_G0033376	protein coding gene	Chr8:70025396-70032493 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034183	protein coding gene	Chr8:72978356-72985498 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031127	protein coding gene	Chr8:62278205-62285270 (+)
CAST/EiJ	MGP_CASTEiJ_G0032701	protein coding gene	Chr8:69506095-69513215 (+)
CBA/J	MGP_CBAJ_G0033354	protein coding gene	Chr8:75620397-75627494 (+)
DBA/2J	MGP_DBA2J_G0033508	protein coding gene	Chr8:67186397-67193486 (+)
FVB/NJ	MGP_FVBNJ_G0033449	protein coding gene	Chr8:66284187-66291284 (+)
LP/J	MGP_LPJ_G0033595	protein coding gene	Chr8:70361646-70368743 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033493	protein coding gene	Chr8:78283765-78290907 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034201	protein coding gene	Chr8:69558189-69565282 (+)
PWK/PhJ	MGP_PWKPhJ_G0032409	protein coding gene	Chr8:66470820-66478007 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032245	protein coding gene	Chr8:68532948-68539808 (+)
WSB/EiJ	MGP_WSBEiJ_G0032816	protein coding gene	Chr8:69920435-69927521 (+)

Human Ortholog

TM6SF2, transmembrane 6 superfamily member 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TM6SF2, transmembrane 6 superfamily member 2
Links

HGNC:11861

NCBI Gene ID: 53345

neXtProt AC: NX_Q9BZW4

UniProt: Q9BZW4
Chr Location

19p13.11; chr19:19264364-19273391 (-) GRCh38

MGI Vertebrate Homology

Tm6sf2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TM6SF2
Gene Tree

Tm6sf2

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Phenotype Summary

20 phenotypes from 3 alleles in 3 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

9
Targeted

4
Genomic Mutations

1 involving Tm6sf2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show hepatosteatosis, hypocholesterolemia, increased serum alanine transaminase level, reduced VLDL-TG secretion, small VLDL particles, and lipid accumulation in enterocytes. Homozygotes for another null allele show reduced total cholesterol and LDL cholesterol levels.

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All GO Annotations

11
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tm6sf2

ZFIN tm6sf2b

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All Sequences

38
RefSeq

4
UniProt

3
CCDS

CCDS22357.1, CCDS80889.1

Ensembl

ENSMUSG00000036151 (Evidence)
NCBI Gene

107770

			Length	Strain/Species	Flank
genomic	107770	NCBI Gene Model \| MGI Sequence Detail	7143	C57BL/6J	± kb
transcript	NM_001293795	RefSeq \| MGI Sequence Detail	1446	C57BL/6
polypeptide	Q8R1J1	UniProt \| EBI \| MGI Sequence Detail	378	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030705 transmembrane 6 superfamily member 2

(term hierarchy)
InterPro Domains

IPR033118 EXPERA domain

IPR047195 Transmembrane 6 superfamily member 1/2

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All nucleic 12

cDNA 12

Microarray probesets 3

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 17
Earliest

J:66727 Carim-Todd L, et al., Cloning of the novel gene TM6SF1 reveals conservation of clusters of paralogous genes between human chromosomes 15q24-->q26 and 19p13.3-->p12. Cytogenet Cell Genet. 2000;90(3-4):255-60
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tm6sf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77697	Chr8:70525460-70525472 (+)	-108 bp
Tssr77698	Chr8:70525546-70525611 (+)	5 bp
Tssr77699	Chr8:70525633-70525656 (+)	71 bp
Tssr77700	Chr8:70525681-70525690 (+)	112 bp
Tssr77701	Chr8:70527100-70527127 (+)	1,540 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24