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Gtf2a1 Gene Detail
Summary
  • Symbol
    Gtf2a1
  • Name
    general transcription factor II A, 1
  • Synonyms
    19kDa, 37kDa, 6330549H03Rik, Tfiia1, TfIIAa/b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933277
    NCBI Gene: 83602
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:91522036-91557261 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 45.02 cM, cytoband E
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    864 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933277
 protein coding gene Chr12:91522036-91559102 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019999
 protein coding gene Chr12:92666069-92706458 (-)
A/J MGP_AJ_G0019954
 protein coding gene Chr12:89191041-89222468 (-)
AKR/J MGP_AKRJ_G0019930
 protein coding gene Chr12:91580607-91617081 (-)
BALB/cJ MGP_BALBcJ_G0019940
 protein coding gene Chr12:89473276-89514561 (-)
C3H/HeJ MGP_C3HHeJ_G0019742
 protein coding gene Chr12:92193231-92232894 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020389
 protein coding gene Chr12:95412802-95457046 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018003
 protein coding gene Chr12:86638478-86667446 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0019714
 protein coding gene Chr12:98981160-99020872 (-)
DBA/2J MGP_DBA2J_G0019825
 protein coding gene Chr12:88661171-88704342 (-)
FVB/NJ MGP_FVBNJ_G0019814
 protein coding gene Chr12:87538831-87578425 (-)
LP/J MGP_LPJ_G0019901
 protein coding gene Chr12:92466258-92509414 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019855
 protein coding gene Chr12:101763217-101808524 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020418
 protein coding gene Chr12:91200230-91230947 (-)
PWK/PhJ MGP_PWKPhJ_G0019052
 protein coding gene Chr12:83255271-83282227 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018848
 protein coding gene Chr12:85346845-85377931 (-)
WSB/EiJ MGP_WSBEiJ_G0019342
 protein coding gene Chr12:91958197-91991447 (-)



Homology
more
  • Human Ortholog
    GTF2A1, general transcription factor IIA subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GTF2A1, general transcription factor IIA subunit 1
  • Synonyms
    TF2A1, TFIIA, TFIIA-42, TFIIAL
  • Links
    NCBI Gene ID: 2957
    neXtProt AC: NX_P52655
    UniProt: P52655

  • Chr Location
    14q31.1; chr14:81175452-81221390 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele where D/G cleavage residues are replaced with noncleavable A/A show neonatal lethality, feeding defects, low testis weight, and male infertility associated with azoospermia, small seminiferous tubules, lack of elongating spermatids, and increased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    65
  • cDNA Data
    19
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020962 Ensembl Gene Model | MGI Sequence Detail 35226 C57BL/6J ±  kb
    transcript ENSMUST00000021345 Ensembl | MGI Sequence Detail 6064 Not Applicable  
    polypeptide ENSMUSP00000021345 Ensembl | MGI Sequence Detail 378 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 21
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915037, MGI:2144740, MGI:2144749, MGI:2144998
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:320280 Roeder RG, The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem Sci. 1996 Sep;21(9):327-35
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory