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Tmprss5 Gene Detail
Summary
  • Symbol
    Tmprss5
  • Name
    transmembrane protease, serine 5 (spinesin)
  • Synonyms
    spinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933407
    NCBI Gene: 80893
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:49013994-49028891 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 26.59 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    441 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933407
 protein coding gene Chr9:48992560-49028891 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034769
 protein coding gene Chr9:47922222-47937019 (+)
A/J MGP_AJ_G0034750
 protein coding gene Chr9:46491867-46506554 (+)
AKR/J MGP_AKRJ_G0034678
 protein coding gene Chr9:47459144-47476078 (+)
BALB/cJ MGP_BALBcJ_G0034742
 protein coding gene Chr9:46209374-46224245 (+)
C3H/HeJ MGP_C3HHeJ_G0034452
 protein coding gene Chr9:47921773-47936501 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035262
 protein coding gene Chr9:49282312-49297100 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032175
 protein coding gene Chr9:45975494-45991015 (+)
CAST/EiJ MGP_CASTEiJ_G0033774
 protein coding gene Chr9:47863262-47880000 (+)
CBA/J MGP_CBAJ_G0034424
 protein coding gene Chr9:51027691-51044520 (+)
DBA/2J MGP_DBA2J_G0034583
 protein coding gene Chr9:46343586-46358589 (+)
FVB/NJ MGP_FVBNJ_G0034524
 protein coding gene Chr9:45591987-45606888 (+)
LP/J MGP_LPJ_G0034664
 protein coding gene Chr9:48288968-48303688 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034568
 protein coding gene Chr9:52710967-52725704 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035283
 protein coding gene Chr9:47408992-47423737 (+)
PWK/PhJ MGP_PWKPhJ_G0033479
 protein coding gene Chr9:46311991-46326888 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033314
 protein coding gene Chr9:47695649-47740417 (+)
WSB/EiJ MGP_WSBEiJ_G0033887
 protein coding gene Chr9:47439377-47455177 (+)



Homology
more
  • Human Ortholog
    TMPRSS5, transmembrane serine protease 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMPRSS5, transmembrane serine protease 5
  • Synonyms
    SPINESIN
  • Links
    NCBI Gene ID: 80975
    neXtProt AC: NX_Q9H3S3
    UniProt: Q9H3S3

  • Chr Location
    11q23.2; chr11:113687547-113706373 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    6
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 80893 NCBI Gene Model | MGI Sequence Detail 14898 C57BL/6J ±  kb
transcript NM_030709 RefSeq | MGI Sequence Detail 2092 C57BL/6  
polypeptide Q9ER04 UniProt | EBI | MGI Sequence Detail 455 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:93168 Watanabe Y, et al., Molecular cloning and tissue-specific expression analysis of mouse spinesin, a type II transmembrane serine protease 5. Biochem Biophys Res Commun. 2004 Nov 5;324(1):333-40
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory