Slc16a3 MGI Mouse Gene Detail - MGI:1933438 - solute carrier family 16 (monocarboxylic acid transporters), member 3

Symbol

Slc16a3
Name

solute carrier family 16 (monocarboxylic acid transporters), member 3
Synonyms

MCT3, MCT4, monocarboxylate transporter 4

Feature Type

protein coding gene
IDs

MGI:1933438
NCBI Gene: 80879
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:120839310-120849826 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 84.73 cM
Mapping Data

1 experiment

SNPs within 2kb

233 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933438	protein coding gene	Chr11:120839306-120851694 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019533	protein coding gene	Chr11:125462327-125476514 (+)
A/J	MGP_AJ_G0019500	protein coding gene	Chr11:119861394-119873775 (+)
AKR/J	MGP_AKRJ_G0019470	protein coding gene	Chr11:123493139-123505644 (+)
BALB/cJ	MGP_BALBcJ_G0019475	protein coding gene	Chr11:120230621-120243032 (+)
C3H/HeJ	MGP_C3HHeJ_G0019281	protein coding gene	Chr11:123815149-123827466 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019924	protein coding gene	Chr11:129277843-129290291 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017549	protein coding gene	Chr11:116849641-116862021 (+)
CAST/EiJ	MGP_CASTEiJ_G0018835	protein coding gene	Chr11:125323602-125336052 (+)
CBA/J	MGP_CBAJ_G0019252	protein coding gene	Chr11:134299326-134311467 (+)
DBA/2J	MGP_DBA2J_G0019365	protein coding gene	Chr11:119236806-119249585 (+)
FVB/NJ	MGP_FVBNJ_G0019356	protein coding gene	Chr11:118954499-118966859 (+)
LP/J	MGP_LPJ_G0019436	protein coding gene	Chr11:125751012-125763369 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019389	protein coding gene	Chr11:133125539-133137821 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019963	protein coding gene	Chr11:124168160-124180486 (+)
PWK/PhJ	MGP_PWKPhJ_G0018601	protein coding gene	Chr11:120675688-120688222 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018393	protein coding gene	Chr11:123924353-123937624 (+)
WSB/EiJ	MGP_WSBEiJ_G0018888	protein coding gene	Chr11:124151434-124163783 (+)

Human Ortholog

SLC16A3, solute carrier family 16 member 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC16A3, solute carrier family 16 member 3
Synonyms

MCT 3, MCT-3, MCT3, MCT 4, MCT-4, MCT4
Links

HGNC:10924

NCBI Gene ID: 9123

neXtProt AC: NX_O15427

UniProt: O15427
Chr Location

17q25.3; chr17:82217934-82261129 (+) GRCh38

MGI Vertebrate Homology

Slc16a3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC16A3
Gene Tree

Slc16a3

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

6
Gene trapped

7
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available

Mice homozygous for a null allele exhibit impaired exercise endurance with abnormal NMJ innervation and lower compound muscle action potential amplitude.

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All GO Annotations

29
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

958
Tissues

171
cDNA Data

85
Literature Summary

39

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc16a3

ZFIN slc16a3b

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All Sequences

64
RefSeq

12
UniProt

6
CCDS

CCDS25761.1

Ensembl

ENSMUSG00000025161 (Evidence)
NCBI Gene

80879

			Length	Strain/Species	Flank
genomic	80879	NCBI Gene Model \| MGI Sequence Detail	10517	C57BL/6J	± kb
transcript	NM_030696	RefSeq \| MGI Sequence Detail	2493	Not Specified
polypeptide	P57787	UniProt \| EBI \| MGI Sequence Detail	470	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000014951 monocarboxylate transporter 4

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR004743 Monocarboxylate transporter

IPR050327 Proton-linked Monocarboxylate Transporter

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All nucleic 90

cDNA 85

Primer pair 5

Microarray probesets 2

Summaries

All 89

Developmental Gene Expression 39

Gene Ontology 7

Phenotypes 21
Earliest

J:76794 Herubel F, et al., Genetic expression of monocarboxylate transporters during human and murine oocyte maturation and early embryonic development. Zygote. 2002 May;10(2):175-81
Latest

J:354591 Jeyarajah MJ, et al., Placental extracellular vesicles promote cardiomyocyte maturation and fetal heart development. Commun Biol. 2024 Oct 3;7(1):1254

TSS for Slc16a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106378	Chr11:120839319-120839359 (+)	29 bp
Tssr106379	Chr11:120839369-120839379 (+)	64 bp
Tssr106380	Chr11:120839540-120839572 (+)	246 bp
Tssr106381	Chr11:120839926-120839940 (+)	623 bp
Tssr106382	Chr11:120840342-120840345 (+)	1,034 bp
Tssr106383	Chr11:120846150-120846186 (+)	6,858 bp
Tssr106384	Chr11:120847361-120847373 (+)	8,057 bp
Tssr106385	Chr11:120848836-120848843 (+)	9,530 bp
Tssr106386	Chr11:120849043-120849062 (+)	9,743 bp
Tssr106387	Chr11:120849218-120849252 (+)	9,925 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24