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Adgrb1 Gene Detail
Summary
  • Symbol
    Adgrb1
  • Name
    adhesion G protein-coupled receptor B1
  • Synonyms
    B830018M07Rik, Bai1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933736
    NCBI Gene: 107831
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:74388045-74461314 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 34.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1742 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933736
 protein coding gene Chr15:74388044-74461314 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021927
 protein coding gene Chr15:74292141-74369550 (+)
A/J MGP_AJ_G0021886
 protein coding gene Chr15:71639716-71713455 (+)
AKR/J MGP_AKRJ_G0021868
 protein coding gene Chr15:73477757-73551163 (+)
BALB/cJ MGP_BALBcJ_G0021893
 protein coding gene Chr15:71647985-71721552 (+)
C3H/HeJ MGP_C3HHeJ_G0021666
 protein coding gene Chr15:73626811-73705336 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022333
 protein coding gene Chr15:77102926-77181023 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019869
 protein coding gene Chr15:68053518-68126471 (+)
CAST/EiJ MGP_CASTEiJ_G0021185
 protein coding gene Chr15:74432929-74514820 (+)
CBA/J MGP_CBAJ_G0021632
 protein coding gene Chr15:79613480-79698909 (+)
DBA/2J MGP_DBA2J_G0021757
 protein coding gene Chr15:71238467-71312215 (+)
FVB/NJ MGP_FVBNJ_G0021739
 protein coding gene Chr15:70277205-70351689 (+)
LP/J MGP_LPJ_G0021829
 protein coding gene Chr15:74334705-74432451 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021762
 protein coding gene Chr15:84946680-85021902 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022354
 protein coding gene Chr15:73860231-73938778 (+)
PWK/PhJ MGP_PWKPhJ_G0020926
 protein coding gene Chr15:71338742-71412987 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020767
 protein coding gene Chr15:73745211-73821916 (+)
WSB/EiJ MGP_WSBEiJ_G0021237
 protein coding gene Chr15:73867340-73948152 (+)



Homology
more
  • Human Ortholog
    ADGRB1, adhesion G protein-coupled receptor B1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADGRB1, adhesion G protein-coupled receptor B1
  • Synonyms
    BAI1, GDAIF
  • Links
    NCBI Gene ID: 575
    neXtProt AC: NX_O14514
    UniProt: O14514

  • Chr Location
    8q24.3; chr8:142449430-142545009 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADGRB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit spatial learning and memory deficits, enhanced long term potentiation, decreased long term depression, abnormal postsynaptic density morphology, and impaired synaptic plasticity in hippocampal neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    27
  • cDNA Data
    36
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107831 NCBI Gene Model | MGI Sequence Detail 73270 C57BL/6J ±  kb
    transcript NM_001359759 RefSeq | MGI Sequence Detail 6256 C57BL/6  
    polypeptide Q3UHD1 UniProt | EBI | MGI Sequence Detail 1582 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 2
      cDNA 36
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146318
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 17
      Phenotypes 42
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:348067 Carlton AJ, et al., BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing. Cell Rep. 2024 Apr 23;43(4):114025
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory