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Rtn1 Gene Detail
Summary
  • Symbol
    Rtn1
  • Name
    reticulon 1
  • Synonyms
    0710005K15Rik, 4930441F12Rik, MGC:40985, Nsp, Rtn1-a, Rtn1-b, Rtn1-c
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933947
    NCBI Gene: 104001
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:72258526-72455828 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 30.20 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6316 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933947
 protein coding gene Chr12:72258523-72455828 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019824
 protein coding gene Chr12:72030800-72238674 (-)
A/J MGP_AJ_G0019782
 protein coding gene Chr12:69347685-69545943 (-)
AKR/J MGP_AKRJ_G0019758
 protein coding gene Chr12:71431703-71639422 (-)
BALB/cJ MGP_BALBcJ_G0019762
 protein coding gene Chr12:69837388-70030804 (-)
C3H/HeJ MGP_C3HHeJ_G0019567
 protein coding gene Chr12:71890709-72090269 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020214
 protein coding gene Chr12:74306868-74516718 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017834
 protein coding gene Chr12:66824210-67014800 (-)
CAST/EiJ MGP_CASTEiJ_G0019119
 protein coding gene Chr12:66649815-66863153 (-)
CBA/J MGP_CBAJ_G0019537
 protein coding gene Chr12:77072782-77293561 (-)
DBA/2J MGP_DBA2J_G0019653
 protein coding gene Chr12:69249526-69448102 (-)
FVB/NJ MGP_FVBNJ_G0019640
 protein coding gene Chr12:68123146-68318013 (-)
LP/J MGP_LPJ_G0019725
 protein coding gene Chr12:72043688-72251539 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019679
 protein coding gene Chr12:80248924-80469220 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020249
 protein coding gene Chr12:70939145-71143990 (-)
PWK/PhJ MGP_PWKPhJ_G0018884
 protein coding gene Chr12:63546568-63744606 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018679
 protein coding gene Chr12:65341116-65549183 (-)
WSB/EiJ MGP_WSBEiJ_G0019170
 protein coding gene Chr12:71533390-71733778 (-)



Homology
more
  • Human Ortholog
    RTN1, reticulon 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTN1, reticulon 1
  • Synonyms
    NSP
  • Links
    NCBI Gene ID: 6252
    neXtProt AC: NX_Q16799
    UniProt: Q16799

  • Chr Location
    14q23.1; chr14:59595976-59870776 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Mice homozygous for a null allele are viable with no gross abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    930
  • Tissues
    70
  • cDNA Data
    129
  • Literature Summary
    13
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021087 Ensembl Gene Model | MGI Sequence Detail 197303 C57BL/6J ±  kb
transcript ENSMUST00000078505 Ensembl | MGI Sequence Detail 3629 Not Applicable  
polypeptide ENSMUSP00000077594 Ensembl | MGI Sequence Detail 780 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR003388 Reticulon
    IPR046964 Reticulon 1-4
  • GlyGen
    Q8K0T0 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 132
    cDNA 131
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1913343, MGI:1926049, MGI:2145135
References
more
  • Summaries
    All 65
    Developmental Gene Expression 13
    Gene Ontology 7
    Phenotypes 16
  • Earliest
    J:46660 Geisler JG, et al., Molecular cloning of a novel mouse gene with predominant muscle and neural expression. Mamm Genome. 1998 Apr;9(4):274-82
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory