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Rbfox2 Gene Detail
Summary
  • Symbol
    Rbfox2
  • Name
    RNA binding protein, fox-1 homolog (C. elegans) 2
  • Synonyms
    2810460A15Rik, Fbm2, Fxh, Rbm9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933973
    NCBI Gene: 93686
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76963190-77191204 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 36.40 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3906 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933973
 protein coding gene Chr15:76963190-77193058 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022021
 protein coding gene Chr15:77224338-77469411 (-)
A/J MGP_AJ_G0021979
 protein coding gene Chr15:74363392-74592594 (-)
AKR/J MGP_AKRJ_G0021962
 protein coding gene Chr15:76399769-76632114 (-)
BALB/cJ MGP_BALBcJ_G0021988
 protein coding gene Chr15:74387427-74617390 (-)
C3H/HeJ MGP_C3HHeJ_G0021760
 protein coding gene Chr15:76437946-76669878 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022428
 protein coding gene Chr15:80088764-80337004 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019957
 protein coding gene Chr15:71010448-71237828 (-)
CAST/EiJ MGP_CASTEiJ_G0021279
 protein coding gene Chr15:77245783-77489009 (-)
CBA/J MGP_CBAJ_G0021727
 protein coding gene Chr15:82625619-82870326 (-)
DBA/2J MGP_DBA2J_G0021852
 protein coding gene Chr15:73907759-74138049 (-)
FVB/NJ MGP_FVBNJ_G0021832
 protein coding gene Chr15:72963258-73191933 (-)
LP/J MGP_LPJ_G0021923
 protein coding gene Chr15:77286876-77527602 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021857
 protein coding gene Chr15:87942141-88182438 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022448
 protein coding gene Chr15:76658114-76892703 (-)
PWK/PhJ MGP_PWKPhJ_G0021020
 protein coding gene Chr15:74076249-74309986 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020860
 protein coding gene Chr15:76378062-76620573 (-)
WSB/EiJ MGP_WSBEiJ_G0021331
 protein coding gene Chr15:76764409-76999344 (-)



Homology
more
  • Human Ortholog
    RBFOX2, RNA binding fox-1 homolog 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBFOX2, RNA binding fox-1 homolog 2
  • Synonyms
    dJ106I20.3, Fox-2, FOX2, fxh, HNRBP2, HRNBP2, RBM9, RTA
  • Links
    NCBI Gene ID: 23543
    neXtProt AC: NX_O43251
    UniProt: O43251

  • Chr Location
    22q12.3; chr22:35738736-36028824 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RBFOX2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 1 allele in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in the brain exhibit normal spontaneous and kainic acid-induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    33
  • cDNA Data
    16
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033565 Ensembl Gene Model | MGI Sequence Detail 228015 C57BL/6J ±  kb
    transcript ENSMUST00000171751 Ensembl | MGI Sequence Detail 6907 Not Applicable  
    polypeptide ENSMUSP00000130739 Ensembl | MGI Sequence Detail 449 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 16
      Primer pair 4

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1920085, MGI:2145891, MGI:2145951, MGI:894685
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 15
      Phenotypes 49
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:343265 Moss ND, et al., Modulation of insulin secretion by RBFOX2-mediated alternative splicing. Nat Commun. 2023 Nov 25;14(1):7732
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory