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Kremen1 Gene Detail
Summary
  • Symbol
    Kremen1
  • Name
    kringle containing transmembrane protein 1
  • Synonyms
    Krm1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933988
    NCBI Gene: 84035
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:5141552-5211558 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 3.36 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1770 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933988
 protein coding gene Chr11:5141551-5212220 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017999
 protein coding gene Chr11:2218851-2293756 (-)
A/J MGP_AJ_G0017972
 protein coding gene Chr11:2153008-2222667 (-)
AKR/J MGP_AKRJ_G0017936
 protein coding gene Chr11:2275104-2351587 (-)
BALB/cJ MGP_BALBcJ_G0017940
 protein coding gene Chr11:2134958-2205640 (-)
C3H/HeJ MGP_C3HHeJ_G0017753
 protein coding gene Chr11:2156161-2227755 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018392
 protein coding gene Chr11:2289685-2362401 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016050
 protein coding gene Chr11:2044932-2114024 (-)
CAST/EiJ MGP_CASTEiJ_G0017315
 protein coding gene Chr11:2114043-2186342 (-)
CBA/J MGP_CBAJ_G0017728
 protein coding gene Chr11:2598262-2679068 (-)
DBA/2J MGP_DBA2J_G0017838
 protein coding gene Chr11:2049738-2122477 (-)
FVB/NJ MGP_FVBNJ_G0017830
 protein coding gene Chr11:2090385-2144339 (-)
LP/J MGP_LPJ_G0017909
 protein coding gene Chr11:2303147-2378592 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017856
 protein coding gene Chr11:2218402-2290259 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018432
 protein coding gene Chr11:2255313-2326558 (-)
PWK/PhJ MGP_PWKPhJ_G0017095
 protein coding gene Chr11:2070963-2144688 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016892
 protein coding gene Chr11:2243462-2315809 (-)
WSB/EiJ MGP_WSBEiJ_G0017369
 protein coding gene Chr11:2123275-2193905 (-)



Homology
more
  • Human Ortholog
    KREMEN1, kringle containing transmembrane protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KREMEN1, kringle containing transmembrane protein 1
  • Synonyms
    ECTD13, KREMEN, KRM1
  • Links
    NCBI Gene ID: 83999
    neXtProt AC: NX_Q96MU8
    UniProt: Q96MU8

  • Chr Location
    22q12.1; chr22:29073035-29168333 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KREMEN1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotypes from multigenic genotypes
    13 phenotype references
Mice homozygous for a null allele exhibit no abnormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1094
  • Tissues
    291
  • cDNA Data
    58
  • Literature Summary
    20
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020393 Ensembl Gene Model | MGI Sequence Detail 70007 C57BL/6J ±  kb
transcript ENSMUST00000020662 Ensembl | MGI Sequence Detail 4856 Not Applicable  
polypeptide ENSMUSP00000020662 Ensembl | MGI Sequence Detail 473 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    cDNA 58
    Primer pair 4
    Other 3

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144448
References
more
  • Summaries
    All 54
    Developmental Gene Expression 20
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:68359 Nakamura T, et al., Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein. Biochim Biophys Acta. 2001 Mar 19;1518(1-2):63-72
  • Latest
    J:349775 Matern MS, et al., Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle. Cell Rep. 2023 Jun 27;42(6):112545
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory