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Pla1a Gene Detail
Summary
  • Symbol
    Pla1a
  • Name
    phospholipase A1 member A
  • Synonyms
    Ps-pla1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934677
    NCBI Gene: 85031
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:38216479-38253507 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    944 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934677
 protein coding gene Chr16:38214245-38253553 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022814
 protein coding gene Chr16:36922794-36961618 (-)
A/J MGP_AJ_G0022779
 protein coding gene Chr16:35090017-35125211 (-)
AKR/J MGP_AKRJ_G0022751
 protein coding gene Chr16:36424912-36460111 (-)
BALB/cJ MGP_BALBcJ_G0022780
 protein coding gene Chr16:35210996-35247894 (-)
C3H/HeJ MGP_C3HHeJ_G0022544
 protein coding gene Chr16:36525314-36563386 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023227
 protein coding gene Chr16:37761087-37802705 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020742
 protein coding gene Chr16:35468303-35502964 (-)
CAST/EiJ MGP_CASTEiJ_G0022070
 protein coding gene Chr16:36683391-36718330 (-)
CBA/J MGP_CBAJ_G0022515
 protein coding gene Chr16:39419577-39459074 (-)
DBA/2J MGP_DBA2J_G0022647
 protein coding gene Chr16:34972998-35010584 (-)
FVB/NJ MGP_FVBNJ_G0022622
 protein coding gene Chr16:35003944-35040887 (-)
LP/J MGP_LPJ_G0022715
 protein coding gene Chr16:36603836-36640927 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022641
 protein coding gene Chr16:38540774-38578283 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023242
 protein coding gene Chr16:36385533-36424949 (-)
PWK/PhJ MGP_PWKPhJ_G0021810
 protein coding gene Chr16:35387784-35424323 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021641
 protein coding gene Chr16:36283478-36319514 (-)
WSB/EiJ MGP_WSBEiJ_G0022114
 protein coding gene Chr16:36457399-36495049 (-)



Homology
more
  • Human Ortholog
    PLA1A, phospholipase A1 member A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLA1A, phospholipase A1 member A
  • Synonyms
    PS-PLA1, PSPLA1
  • Links
    NCBI Gene ID: 51365
    neXtProt AC: NX_Q53H76
    UniProt: Q53H76

  • Chr Location
    3q13.33; chr3:119597875-119629811 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are slightly smaller, have an enlarged liver, and a slight increase in lymphocytes. Mice develop less severe mannan-induced psoriatic arthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    48
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002847 Ensembl Gene Model | MGI Sequence Detail 37029 C57BL/6J ±  kb
    transcript ENSMUST00000002926 Ensembl | MGI Sequence Detail 1974 Not Applicable  
    polypeptide ENSMUSP00000002926 Ensembl | MGI Sequence Detail 456 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 48
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146373
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:69110 Wen XY, et al., Murine phosphatidylserine-specific phospholipase A1 (Ps-pla1) maps to chromosome 16 but is distinct from the lpd (lipid defect) locus. Mamm Genome. 2001 Feb;12(2):129-32
    • Latest
      J:357410 Tam H, et al., Phosphatidylserine phospholipase A1 enables GPR34-dependent immune cell accumulation in the peritoneal cavity. J Exp Med. 2024 Nov 4;221(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory