Rnf31 MGI Mouse Gene Detail - MGI:1934704

Symbol

Rnf31
Name

ring finger protein 31
Synonyms

HOIP, Paul

Feature Type

protein coding gene
IDs

MGI:1934704
NCBI Gene: 268749
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr14:55829199-55841131 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM
Mapping Data

2 experiments

SNPs within 2kb

244 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1934704	protein coding gene	Chr14:55829165-55841150 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021354	protein coding gene	Chr14:49628223-49640214 (+)
A/J	MGP_AJ_G0021313	protein coding gene	Chr14:48639756-48651735 (+)
AKR/J	MGP_AKRJ_G0021289	protein coding gene	Chr14:50385635-50397618 (+)
BALB/cJ	MGP_BALBcJ_G0021317	protein coding gene	Chr14:48585512-48597523 (+)
C3H/HeJ	MGP_C3HHeJ_G0021097	protein coding gene	Chr14:50070771-50082755 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021755	protein coding gene	Chr14:52122453-52134429 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019302	protein coding gene	Chr14:47015172-47026981 (+)
CAST/EiJ	MGP_CASTEiJ_G0020616	protein coding gene	Chr14:46335416-46347386 (+)
CBA/J	MGP_CBAJ_G0021064	protein coding gene	Chr14:53676345-53688340 (+)
DBA/2J	MGP_DBA2J_G0021185	protein coding gene	Chr14:48364725-48376712 (+)
FVB/NJ	MGP_FVBNJ_G0021167	protein coding gene	Chr14:47812712-47824635 (+)
LP/J	MGP_LPJ_G0021259	protein coding gene	Chr14:50672196-50684173 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021191	protein coding gene	Chr14:53039392-53051320 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021782	protein coding gene	Chr14:49572952-49584943 (+)
PWK/PhJ	MGP_PWKPhJ_G0020363	protein coding gene	Chr14:44896366-44908458 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020191	protein coding gene	Chr14:45577746-45589388 (+)
WSB/EiJ	MGP_WSBEiJ_G0020669	protein coding gene	Chr14:49859153-49871080 (+)

Human Ortholog

RNF31, ring finger protein 31

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF31, ring finger protein 31
Synonyms

HOIP, IMD115, Paul, ZIBRA
Links

HGNC:16031

NCBI Gene ID: 55072

neXtProt AC: NX_Q96EP0

UniProt: Q96EP0
Chr Location

14q12; chr14:24146683-24160660 (+) GRCh38

MGI Vertebrate Homology

Rnf31 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RNF31
Gene Tree

Rnf31

Diseases

1 with human RNF31 associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

19 phenotypes from 3 alleles in 3 genetic backgrounds
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

1
Targeted

12
Genomic Mutations

1 involving Rnf31
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit complete embryonic lethality. Mice homozygous for a conditional allele activated in B cells exhibit severely impaired B1 B cell development and impaired antibody responses to both T cell-dependent and T cell-independent type 2 antigens.

less

All GO Annotations

46
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

818
Tissues

62
cDNA Data

42
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf31

less

All Sequences

51
RefSeq

2
UniProt

5
CCDS

CCDS27118.1

Ensembl

ENSMUSG00000047098 (Evidence)
NCBI Gene

268749

			Length	Strain/Species	Flank
genomic	268749	NCBI Gene Model \| MGI Sequence Detail	11933	C57BL/6J	± kb
transcript	NM_194346	RefSeq \| MGI Sequence Detail	3432	C57BL/6
polypeptide	Q924T7	UniProt \| EBI \| MGI Sequence Detail	1066	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000014129 E3 ubiquitin-protein ligase RNF31

(term hierarchy)
PDB

5Y3T
EC

2.3.2.31
InterPro Domains

IPR026254 E3 ubiquitin-protein ligase RNF31-like

IPR047543 E3 ubiquitin-protein ligase RNF31-like, Bbox1 zinc finger

IPR047540 E3 ubiquitin-protein ligase RNF31-like, BRcat domain

IPR047541 E3 ubiquitin-protein ligase RNF31-like, modified RING finger, HC subclass

IPR047542 E3 ubiquitin-protein ligase RNF31-like, Rcat domain

IPR040641 E3 ubiquitin-protein ligase RNF31, PUB domain

IPR047539 E3 ubiquitin-protein ligase RNF31, UBA domain

IPR032065 E3 ubiquitin-protein ligase RNF31, UBA-like domain

IPR002867 IBR domain

IPR018997 PUB domain

IPR036339 PUB-like domain superfamily

IPR041031 RNF31, C-terminal

IPR044066 TRIAD supradomain

IPR015940 Ubiquitin-associated domain

IPR001876 Zinc finger, RanBP2-type

IPR036443 Zinc finger, RanBP2-type superfamily

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR017907 Zinc finger, RING-type, conserved site

less

All nucleic 44

cDNA 42

Primer pair 1

Other 1

Microarray probesets 1

less

MGI:2145719, MGI:2448574

Summaries

All 77

Developmental Gene Expression 7

Gene Ontology 15

Phenotypes 31
Earliest

J:68979 Yawata M, et al., Nucleotide sequence analysis of the approximately 35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes. Immunogenetics. 2001 Mar;53(2):119-29
Latest

J:347085 Fu Y, et al., Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis. Nat Commun. 2024 Apr 6;15(1):2974

TSS for Rnf31:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125784	Chr14:55828442-55828463 (+)	-746 bp
Tssr125785	Chr14:55828618-55828632 (+)	-574 bp
Tssr125786	Chr14:55829182-55829242 (+)	13 bp
Tssr125787	Chr14:55829243-55829266 (+)	56 bp
Tssr125788	Chr14:55829276-55829316 (+)	97 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24