Nucks1 MGI Mouse Gene Detail - MGI:1934811 - nuclear casein kinase and cyclin-dependent kinase substrate 1

Symbol

Nucks1
Name

nuclear casein kinase and cyclin-dependent kinase substrate 1
Synonyms

2700010L10Rik, 8430423A01Rik, Nucks

Feature Type

protein coding gene
IDs

MGI:1934811
NCBI Gene: 98415
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:131838272-131864059 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 57.22 cM
Mapping Data

2 experiments

SNPs within 2kb

530 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1934811	protein coding gene	Chr1:131838196-131864059 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016462	protein coding gene	Chr1:135354939-135384910 (+)
A/J	MGP_AJ_G0016445	protein coding gene	Chr1:130350821-130378357 (+)
AKR/J	MGP_AKRJ_G0016410	protein coding gene	Chr1:134176311-134204094 (+)
BALB/cJ	MGP_BALBcJ_G0016405	protein coding gene	Chr1:130669579-130697517 (+)
C3H/HeJ	MGP_C3HHeJ_G0016231	protein coding gene	Chr1:134323934-134351587 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016866	protein coding gene	Chr1:140400197-140428880 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014577	protein coding gene	Chr1:123500738-123524250 (+)
CAST/EiJ	MGP_CASTEiJ_G0015811	protein coding gene	Chr1:133316379-133350319 (+)
CBA/J	MGP_CBAJ_G0016203	protein coding gene	Chr1:145175726-145204660 (+)
DBA/2J	MGP_DBA2J_G0016310	protein coding gene	Chr1:129313439-129341411 (+)
FVB/NJ	MGP_FVBNJ_G0016309	protein coding gene	Chr1:127937335-127963944 (+)
LP/J	MGP_LPJ_G0016381	protein coding gene	Chr1:136672586-136702864 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016334	protein coding gene	Chr1:150949071-150993249 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016902	protein coding gene	Chr1:133936742-133962483 (+)
PWK/PhJ	MGP_PWKPhJ_G0015597	protein coding gene	Chr1:128280813-128301598 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015384	protein coding gene	Chr1:132884912-132910897 (+)
WSB/EiJ	MGP_WSBEiJ_G0015873	protein coding gene	Chr1:133924556-133950203 (+)

Human Ortholog

NUCKS1, nuclear casein kinase and cyclin dependent kinase substrate 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUCKS1, nuclear casein kinase and cyclin dependent kinase substrate 1
Synonyms

JC7, NUCKS
Links

HGNC:29923

NCBI Gene ID: 64710

neXtProt AC: NX_Q9H1E3

UniProt: Q9H1E3
Chr Location

1q32.1; chr1:205712822-205750182 (-) GRCh38

MGI Vertebrate Homology

Nucks1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NUCKS1
Gene Tree

Nucks1

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Phenotype Summary

35 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

167
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

157
Radiation induced

1
Targeted

5
Genomic Mutations

3 involving Nucks1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

68 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous KO leads to increased body fat, reduced energy expenditure, hypoactivity, reduced glucose tolerance, increased insulin levels and insulin resistance.

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All GO Annotations

51
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

13
cDNA Data

10
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nucks1

ZFIN nucks1a

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All Sequences

46
RefSeq

4
UniProt

2
CCDS

CCDS48356.1, CCDS78678.1

Ensembl

ENSMUSG00000026434 (Evidence)
NCBI Gene

98415

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026434	Ensembl Gene Model \| MGI Sequence Detail	25788	C57BL/6J	± kb
transcript	ENSMUST00000062264	Ensembl \| MGI Sequence Detail	5998	Not Applicable
polypeptide	ENSMUSP00000062576	Ensembl \| MGI Sequence Detail	234	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011481 nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

(term hierarchy)
InterPro Domains

IPR052003 Homologous Recombination DNA-Binding Protein

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All nucleic 13

cDNA 11

Primer pair 1

Other 1

Microarray probesets 8

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MGI:1919821, MGI:2138310, MGI:2138671

Summaries

All 51

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 20
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nucks1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8686	Chr1:131838221-131838277 (+)	-23 bp
Tssr8687	Chr1:131838296-131838310 (+)	31 bp
Tssr8688	Chr1:131838417-131838440 (+)	157 bp
Tssr8689	Chr1:131846747-131846760 (+)	8,482 bp
Tssr8690	Chr1:131859757-131859775 (+)	21,494 bp
Tssr8691	Chr1:131859783-131859790 (+)	21,515 bp
Tssr8692	Chr1:131859809-131859823 (+)	21,544 bp
Tssr8693	Chr1:131859856-131859872 (+)	21,592 bp
Tssr8694	Chr1:131863027-131863051 (+)	24,767 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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