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Sez6l Gene Detail
Summary
  • Symbol
    Sez6l
  • Name
    seizure related 6 homolog like
  • Synonyms
    Acig1, mKIAA0927
  • Feature Type
    protein coding gene
  • IDs
    MGI:1935121
    NCBI Gene: 56747
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:112567017-112725051 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 54.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4972 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1935121
 protein coding gene Chr5:112567017-112726401 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029908
 protein coding gene Chr5:114999660-115167482 (-)
A/J MGP_AJ_G0029874
 protein coding gene Chr5:110523767-110684309 (-)
AKR/J MGP_AKRJ_G0029812
 protein coding gene Chr5:114033510-114196472 (-)
BALB/cJ MGP_BALBcJ_G0029885
 protein coding gene Chr5:111883918-112046630 (-)
C3H/HeJ MGP_C3HHeJ_G0029605
 protein coding gene Chr5:114474138-114635981 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030338
 protein coding gene Chr5:119497261-119657406 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027567
 protein coding gene Chr5:105346756-105510405 (-)
CAST/EiJ MGP_CASTEiJ_G0029013
 protein coding gene Chr5:113381777-113544242 (-)
CBA/J MGP_CBAJ_G0029572
 protein coding gene Chr5:123973780-124150438 (-)
DBA/2J MGP_DBA2J_G0029722
 protein coding gene Chr5:110591377-110749697 (-)
FVB/NJ MGP_FVBNJ_G0029679
 protein coding gene Chr5:109317297-109480010 (-)
LP/J MGP_LPJ_G0029810
 protein coding gene Chr5:115565883-115730733 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029710
 protein coding gene Chr5:128561839-128740112 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030379
 protein coding gene Chr5:113466040-113629664 (-)
PWK/PhJ MGP_PWKPhJ_G0028727
 protein coding gene Chr5:109202226-109364852 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028565
 protein coding gene Chr5:110953275-111117450 (-)
WSB/EiJ MGP_WSBEiJ_G0029089
 protein coding gene Chr5:113985839-114152606 (-)



Homology
more
  • Human Ortholog
    SEZ6L, seizure related 6 homolog like
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEZ6L, seizure related 6 homolog like
  • Synonyms
    SEZ6L1
  • Links
    NCBI Gene ID: 23544
    neXtProt AC: NX_Q9BYH1
    UniProt: Q9BYH1

  • Chr Location
    22q12.1; chr22:26169462-26383597 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display slightly impaired coordination in the rotarod task.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    33
  • cDNA Data
    80
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058153 Ensembl Gene Model | MGI Sequence Detail 158035 C57BL/6J ±  kb
    transcript ENSMUST00000212480 Ensembl | MGI Sequence Detail 5857 Not Applicable  
    polypeptide ENSMUSP00000148791 Ensembl | MGI Sequence Detail 964 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 80

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140978, MGI:2141215
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 7
      Gene Ontology 4
      Phenotypes 21
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory