Pcdhga12 MGI Mouse Gene Detail - MGI:1935229 - protocadherin gamma subfamily A, 12

Symbol

Pcdhga12
Name

protocadherin gamma subfamily A, 12
Synonyms

pc2c, Pcdh13

Feature Type

protein coding gene
IDs

MGI:1935229
NCBI Gene: 93724
Member of

Pcdhg cluster
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr18:37898633-37974926 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.63 cM, cytoband C
Mapping Data

4 experiments

SNPs within 2kb

2057 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1935229	protein coding gene	Chr18:37898633-37974926 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024350	protein coding gene	Chr18:36173156-36259977 (+)
A/J	MGP_AJ_G0024317	protein coding gene	Chr18:34934357-35011794 (+)
AKR/J	MGP_AKRJ_G0024286	protein coding gene	Chr18:35892351-35972570 (+)
BALB/cJ	MGP_BALBcJ_G0024317	protein coding gene	Chr18:35000318-35077409 (+)
C3H/HeJ	MGP_C3HHeJ_G0024083	protein coding gene	Chr18:35961160-36038769 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024759	protein coding gene	Chr18:37473111-37559702 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022198	protein coding gene	Chr18:34951408-35028291 (+)
CAST/EiJ	MGP_CASTEiJ_G0023558	protein coding gene	Chr18:35896091-35977834 (+)
CBA/J	MGP_CBAJ_G0024053	protein coding gene	Chr18:38583608-38667943 (+)
DBA/2J	MGP_DBA2J_G0024183	protein coding gene	Chr18:34534525-34611340 (+)
FVB/NJ	MGP_FVBNJ_G0024149	protein coding gene	Chr18:34243771-34321591 (+)
LP/J	MGP_LPJ_G0024267	protein coding gene	Chr18:36243325-36321813 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024180	protein coding gene	Chr18:39846841-39929365 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024808	protein coding gene	Chr18:35745619-35837204 (+)
PWK/PhJ	MGP_PWKPhJ_G0023302	protein coding gene	Chr18:34738454-34819114 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023107	protein coding gene	Chr18:35973956-36054330 (+)
WSB/EiJ	MGP_WSBEiJ_G0023621	protein coding gene	Chr18:35650640-35737854 (+)

Human Ortholog

PCDHGA12, protocadherin gamma subfamily A, 12

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PCDHGA12, protocadherin gamma subfamily A, 12
Synonyms

CDH21, FIB3, PCDH-GAMMA-A12
Links

HGNC:8699

NCBI Gene ID: 26025

neXtProt AC: NX_O60330

UniProt: O60330
Chr Location

5q31.3; chr5:141430507-141512975 (+) GRCh38

MGI Vertebrate Homology

Pcdhga12 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: PCDHGA12
Gene Tree

Pcdhga12

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Phenotype Summary

4 phenotype references

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

5 involving Pcdhga12
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

80 strains or lines available

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

908
Tissues

67
cDNA Data

11
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

2
UniProt

7
CCDS

CCDS29191.1

Ensembl

ENSMUSG00000102428 (Evidence)
NCBI Gene

93724

			Length	Strain/Species	Flank
genomic	93724	NCBI Gene Model \| MGI Sequence Detail	76294	C57BL/6J	± kb
transcript	NM_033595	RefSeq \| MGI Sequence Detail	5080	C57BL/6
polypeptide	NP_291073	RefSeq \| MGI Sequence Detail	932	C57BL/6

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UniProt

7 Sequences
InterPro Domains

IPR020894 Cadherin conserved site

IPR031904 Cadherin, C-terminal catenin-binding domain

IPR032455 Cadherin, cytoplasmic C-terminal domain

IPR002126 Cadherin-like

IPR015919 Cadherin-like superfamily

IPR013164 Cadherin, N-terminal

IPR050174 Protocadherin/Cadherin-related Cell Adhesion
GlyGen

Q91XY7 1 site, 1 N-linked glycan (1 site)

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All nucleic 19

Genomic 2

cDNA 12

Primer pair 3

Other 2

Microarray probesets 1

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MGI:1353490

Summaries

All 30

Developmental Gene Expression 9

Gene Ontology 3

Phenotypes 4
Earliest

J:60527 Hirano S, et al., Protocadherin 2C: a new member of the protocadherin 2 subfamily expressed in a redundant manner with OL-protocadherin in the developing brain. Biochem Biophys Res Commun. 1999 Jul 14;260(3):641-5
Latest

J:332241 Kobayashi H, et al., Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality. iScience. 2023 Jan 20;26(1):105766

TSS for Pcdhga12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150735	Chr18:37899011-37899061 (+)	403 bp
Tssr150736	Chr18:37901391-37901432 (+)	2,779 bp
Tssr150737	Chr18:37901433-37901447 (+)	2,807 bp
Tssr150738	Chr18:37901463-37901474 (+)	2,836 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24