Igsf9 MGI Mouse Gene Detail - MGI:2135283 - immunoglobulin superfamily, member 9

Symbol

Igsf9
Name

immunoglobulin superfamily, member 9
Synonyms

Dasm1, mKIAA1355, NRT1

Feature Type

protein coding gene
IDs

MGI:2135283
NCBI Gene: 93842
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:172309355-172326445 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.86 cM
Mapping Data

3 experiments

SNPs within 2kb

423 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2135283	protein coding gene	Chr1:172307616-172326445 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016789	protein coding gene	Chr1:178351029-178368082 (+)
A/J	MGP_AJ_G0016768	protein coding gene	Chr1:171060057-171079026 (+)
AKR/J	MGP_AKRJ_G0016734	protein coding gene	Chr1:176223254-176240309 (+)
BALB/cJ	MGP_BALBcJ_G0016729	protein coding gene	Chr1:171598165-171615234 (+)
C3H/HeJ	MGP_C3HHeJ_G0016553	protein coding gene	Chr1:176797201-176814260 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017191	protein coding gene	Chr1:184277152-184294238 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014897	protein coding gene	Chr1:162752787-162769811 (+)
CAST/EiJ	MGP_CASTEiJ_G0016133	protein coding gene	Chr1:176165966-176183057 (+)
CBA/J	MGP_CBAJ_G0016527	protein coding gene	Chr1:190822930-190840096 (+)
DBA/2J	MGP_DBA2J_G0016634	protein coding gene	Chr1:169985618-170002744 (+)
FVB/NJ	MGP_FVBNJ_G0016631	protein coding gene	Chr1:168241504-168259549 (+)
LP/J	MGP_LPJ_G0016705	protein coding gene	Chr1:179435813-179452887 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016658	protein coding gene	Chr1:198056818-198073871 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017227	protein coding gene	Chr1:176092935-176111033 (+)
PWK/PhJ	MGP_PWKPhJ_G0015919	protein coding gene	Chr1:169367045-169384213 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015701	protein coding gene	Chr1:175050097-175067189 (+)
WSB/EiJ	MGP_WSBEiJ_G0016195	protein coding gene	Chr1:176244144-176262816 (+)

Human Ortholog

IGSF9, immunoglobulin superfamily member 9

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IGSF9, immunoglobulin superfamily member 9
Synonyms

FP18798, IGSF9A, Nrt1
Links

HGNC:18132

NCBI Gene ID: 57549

neXtProt AC: NX_Q9P2J2

UniProt: Q9P2J2
Chr Location

1q23.2; chr1:159927039-159945613 (-) GRCh38

MGI Vertebrate Homology

Igsf9 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: IGSF9
Gene Tree

Igsf9

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Phenotype Summary

7 phenotypes from 3 alleles in 3 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

2
Targeted

4
Genomic Mutations

2 involving Igsf9
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null mutation are viable and fertile but show abnormal miniature inhibitory postsynaptic currents and increased susceptibility to pharmacologically induced seizures.

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

922
Tissues

69
cDNA Data

105
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase igsf9

ZFIN igsf9b

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All Sequences

78
RefSeq

26
UniProt

4
CCDS

CCDS15515.1

Ensembl

ENSMUSG00000037995 (Evidence)
NCBI Gene

93842

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037995	Ensembl Gene Model \| MGI Sequence Detail	17091	C57BL/6J	± kb
transcript	ENSMUST00000052629	Ensembl \| MGI Sequence Detail	4133	Not Applicable
polypeptide	ENSMUSP00000058275	Ensembl \| MGI Sequence Detail	1179	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008972 protein turtle homolog A

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR051170 Neural and epithelial cell adhesion domain-containing protein
GlyGen

Q05BQ1 5 sites

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All nucleic 114

Genomic 1

cDNA 106

Primer pair 4

Other 3

Microarray probesets 2

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MGI:2135331

Summaries

All 39

Developmental Gene Expression 9

Gene Ontology 4

Phenotypes 13
Earliest

J:68343 Doudney K, et al., Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23. Genomics. 2001 Mar 1;72(2):180-92
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Igsf9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10201	Chr1:172309332-172309359 (+)	-9 bp
Tssr10202	Chr1:172309367-172309386 (+)	22 bp
Tssr10203	Chr1:172309469-172309474 (+)	117 bp
Tssr10204	Chr1:172309779-172309798 (+)	434 bp
Tssr301	Chr1:172311837-172311841 (+)	2,484 bp
Tssr10205	Chr1:172319747-172319759 (+)	10,398 bp
Tssr10206	Chr1:172323840-172323860 (+)	14,495 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24