Lin7a MGI Mouse Gene Detail - MGI:2135609 - lin-7 homolog A, crumbs cell polarity complex component

Symbol

Lin7a
Name

lin-7 homolog A, crumbs cell polarity complex component
Synonyms

LIN-7A, MALS-1, TIP-33, Veli

Feature Type

protein coding gene
IDs

MGI:2135609
NCBI Gene: 108030
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr10:107107547-107257335 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 55.83 cM
Mapping Data

2 experiments

SNPs within 2kb

4412 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2135609	protein coding gene	Chr10:107107410-107261007 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017707	protein coding gene	Chr10:109450394-109606717 (+)
A/J	MGP_AJ_G0017684	protein coding gene	Chr10:105362060-105511051 (+)
AKR/J	MGP_AKRJ_G0017646	protein coding gene	Chr10:108429728-108575971 (+)
BALB/cJ	MGP_BALBcJ_G0017648	protein coding gene	Chr10:105749362-105900493 (+)
C3H/HeJ	MGP_C3HHeJ_G0017473	protein coding gene	Chr10:108517822-108672619 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018105	protein coding gene	Chr10:113257353-113416687 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0017034	protein coding gene	Chr10:108614966-108766876 (+)
CBA/J	MGP_CBAJ_G0017442	protein coding gene	Chr10:117661072-117826666 (+)
DBA/2J	MGP_DBA2J_G0017547	protein coding gene	Chr10:104498403-104649692 (+)
FVB/NJ	MGP_FVBNJ_G0017541	protein coding gene	Chr10:103499844-103648620 (+)
LP/J	MGP_LPJ_G0017621	protein coding gene	Chr10:110080097-110235443 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017571	protein coding gene	Chr10:120175926-120343897 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018143	protein coding gene	Chr10:108404580-108564909 (+)
PWK/PhJ	MGP_PWKPhJ_G0016816	protein coding gene	Chr10:104553555-104700950 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016606	protein coding gene	Chr10:107161481-107304617 (+)
WSB/EiJ	MGP_WSBEiJ_G0017094	protein coding gene	Chr10:108525108-108683178 (+)

Human Ortholog

LIN7A, lin-7 homolog A, crumbs cell polarity complex component

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LIN7A, lin-7 homolog A, crumbs cell polarity complex component
Synonyms

LIN7, LIN-7A, MALS-1, MALS1, TIP-33, VELI1
Links

HGNC:17787

NCBI Gene ID: 8825

neXtProt AC: NX_O14910

UniProt: O14910
Chr Location

12q21.31; chr12:80792520-80937934 (-) GRCh38

MGI Vertebrate Homology

Lin7a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LIN7A
Protein SuperFamily

Lin-7_homologue
Gene Tree

Lin7a

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotypes from multigenic genotypes
11 phenotype references

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

1
Genomic Mutations

1 involving Lin7a
Incidental Mutations

CvDC
Find Mice (IMSR)

23 strains or lines available

Mice homozygous for disruptions in this gene display a normal phenotype.

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All GO Annotations

29
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

886
Tissues

31
cDNA Data

30
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lin7a

ZFIN lin7a

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All Sequences

53
RefSeq

12
UniProt

2
CCDS

CCDS24160.1, CCDS36050.1

Ensembl

ENSMUSG00000019906 (Evidence)
NCBI Gene

108030

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019906	Ensembl Gene Model \| MGI Sequence Detail	149789	C57BL/6J	± kb
transcript	ENSMUST00000020057	Ensembl \| MGI Sequence Detail	2363	Not Applicable
polypeptide	ENSMUSP00000020057	Ensembl \| MGI Sequence Detail	233	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009825 protein lin-7 homolog A

(term hierarchy)
InterPro Domains

IPR004172 L27 domain

IPR014775 L27 domain, C-terminal

IPR036892 L27 domain superfamily

IPR051109 Membrane-associated multiprotein complex regulator

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR017365 Protein lin-7
GlyGen

Q8JZS0 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 31

cDNA 30

Primer pair 1

Microarray probesets 7

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MGI:2143687

Summaries

All 55

Developmental Gene Expression 8

Gene Ontology 14

Phenotypes 11
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:304253 Jones MR, et al., A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Front Genet. 2018;9:746

TSS for Lin7a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95642	Chr10:107107189-107107225 (+)	-340 bp
Tssr95643	Chr10:107107478-107107557 (+)	-29 bp
Tssr95644	Chr10:107107558-107107581 (+)	23 bp
Tssr95645	Chr10:107107688-107107711 (+)	153 bp
Tssr95646	Chr10:107107729-107107749 (+)	192 bp
Tssr95647	Chr10:107107751-107107762 (+)	210 bp
Tssr95648	Chr10:107185767-107185779 (+)	78,226 bp
Tssr95649	Chr10:107257093-107257099 (+)	149,549 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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