Glrx MGI Mouse Gene Detail - MGI:2135625

Symbol

Glrx
Name

glutaredoxin
Synonyms

D13Wsu156e, Grx1, TTase

Feature Type

protein coding gene
IDs

MGI:2135625
NCBI Gene: 93692
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr13:75988004-75998270 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 40.95 cM
Mapping Data

4 experiments

SNPs within 2kb

299 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2135625	protein coding gene	Chr13:75987987-75998273 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020772	protein coding gene	Chr13:76376783-76387410 (+)
A/J	MGP_AJ_G0020728	protein coding gene	Chr13:73771607-73782020 (+)
AKR/J	MGP_AKRJ_G0020701	protein coding gene	Chr13:76017974-76030429 (+)
BALB/cJ	MGP_BALBcJ_G0020724	protein coding gene	Chr13:74252926-74263135 (+)
C3H/HeJ	MGP_C3HHeJ_G0020518	protein coding gene	Chr13:75716666-75727081 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021161	protein coding gene	Chr13:78953672-78965235 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018729	protein coding gene	Chr13:70600235-70611191 (+)
CAST/EiJ	MGP_CASTEiJ_G0020036	protein coding gene	Chr13:74821469-74831097 (+)
CBA/J	MGP_CBAJ_G0020477	protein coding gene	Chr13:81949067-81960322 (+)
DBA/2J	MGP_DBA2J_G0020602	protein coding gene	Chr13:73495576-73505772 (+)
FVB/NJ	MGP_FVBNJ_G0020582	protein coding gene	Chr13:72549370-72559577 (+)
LP/J	MGP_LPJ_G0020675	protein coding gene	Chr13:76658912-76670560 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020611	protein coding gene	Chr13:80341543-80352490 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021201	protein coding gene	Chr13:75337998-75349280 (+)
PWK/PhJ	MGP_PWKPhJ_G0019789	protein coding gene	Chr13:72387799-72397520 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019612	protein coding gene	Chr13:71720978-71734539 (+)
WSB/EiJ	MGP_WSBEiJ_G0020093	protein coding gene	Chr13:75843087-75853712 (+)

Human Ortholog

GLRX, glutaredoxin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GLRX, glutaredoxin
Synonyms

GRX, GRX1
Links

HGNC:4330

NCBI Gene ID: 2745

neXtProt AC: NX_P35754

UniProt: P35754
Chr Location

5q15; chr5:95751319-95822726 (-) GRCh38

MGI Vertebrate Homology

Glrx stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: GLRX
Gene Tree

Glrx

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Phenotype Summary

9 phenotypes from 2 alleles in 1 genetic background
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

4
Genomic Mutations

1 involving Glrx
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele do not exhibit any increased injury in response to oxidative insults to the heart or lungs but mouse embryonic fibroblast derived from these embryos are more sensative to diquat and paraqut and more resistant to apoptosis induced by TNF-alpha plus actinomyosin D.

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

806
Tissues

96
cDNA Data

117
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase glrx

ZFIN glrx

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All Sequences

46
RefSeq

4
UniProt

3
CCDS

CCDS26651.1

Ensembl

ENSMUSG00000021591 (Evidence)
NCBI Gene

93692

			Length	Strain/Species	Flank
genomic	93692	NCBI Gene Model \| MGI Sequence Detail	10267	C57BL/6J	± kb
transcript	NM_053108	RefSeq \| MGI Sequence Detail	1335	ZRU/MplStud
polypeptide	Q9QUH0	UniProt \| EBI \| MGI Sequence Detail	107	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008047 glutaredoxin-1

(term hierarchy)
InterPro Domains

IPR002109 Glutaredoxin

IPR047185 Glutaredoxin-1

IPR011767 Glutaredoxin active site

IPR011899 Glutaredoxin, eukaryotic/virial

IPR014025 Glutaredoxin subgroup

IPR036249 Thioredoxin-like superfamily

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All nucleic 119

cDNA 118

Primer pair 1

Microarray probesets 4

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MGD-MRK-36165, MGI:107593, MGI:2145532

Summaries

All 79

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 31
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:353938 Zhang J, et al., The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function. Exp Eye Res. 2023 Jun 3;233:109521

TSS for Glrx:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120401	Chr13:75987993-75988000 (+)	-7 bp
Tssr120402	Chr13:75988016-75988047 (+)	28 bp
Tssr120403	Chr13:75988121-75988163 (+)	138 bp
Tssr120404	Chr13:75988190-75988204 (+)	193 bp
Tssr120405	Chr13:75993215-75993219 (+)	5,213 bp
Tssr120406	Chr13:75993745-75993751 (+)	5,744 bp
Tssr120407	Chr13:75995287-75995310 (+)	7,295 bp
Tssr120408	Chr13:75997435-75997446 (+)	9,437 bp
Tssr120409	Chr13:75997458-75997487 (+)	9,469 bp
Tssr120410	Chr13:75997493-75997502 (+)	9,494 bp
Tssr120411	Chr13:75997534-75997551 (+)	9,539 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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