Sbk1 MGI Mouse Gene Detail - MGI:2135937

Symbol

Sbk1
Name

SH3-binding kinase 1

Feature Type

protein coding gene
IDs

MGI:2135937
NCBI Gene: 104175
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr7:125848034-125894188 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.01 cM, cytoband F1-F3
Mapping Data

1 experiment

SNPs within 2kb

1117 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2135937	protein coding gene	Chr7:125847524-125894188 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032974	protein coding gene	Chr7:130521910-130546274 (+)
A/J	MGP_AJ_G0032957	protein coding gene	Chr7:127087538-127109899 (+)
AKR/J	MGP_AKRJ_G0032889	protein coding gene	Chr7:130297043-130320937 (+)
BALB/cJ	MGP_BALBcJ_G0032962	protein coding gene	Chr7:126744278-126767376 (+)
C3H/HeJ	MGP_C3HHeJ_G0032672	protein coding gene	Chr7:130221905-130244282 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033468	protein coding gene	Chr7:135613691-135636249 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030440	protein coding gene	Chr7:128288102-128310002 (+)
CAST/EiJ	MGP_CASTEiJ_G0032000	protein coding gene	Chr7:122019022-122041139 (+)
CBA/J	MGP_CBAJ_G0032645	protein coding gene	Chr7:140178130-140200538 (+)
DBA/2J	MGP_DBA2J_G0032797	protein coding gene	Chr7:125064405-125087220 (+)
FVB/NJ	MGP_FVBNJ_G0032750	protein coding gene	Chr7:124906141-124929503 (+)
LP/J	MGP_LPJ_G0032891	protein coding gene	Chr7:131982712-132004937 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032782	protein coding gene	Chr7:141385585-141409576 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033488	protein coding gene	Chr7:129309795-129332956 (+)
PWK/PhJ	MGP_PWKPhJ_G0031708	protein coding gene	Chr7:118050076-118072613 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031554	protein coding gene	Chr7:116130678-116152781 (+)
WSB/EiJ	MGP_WSBEiJ_G0032113	protein coding gene	Chr7:130276017-130298709 (+)

Human Ortholog

SBK1, SH3 domain binding kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SBK1, SH3 domain binding kinase 1
Synonyms

SBK
Links

HGNC:17699

NCBI Gene ID: 388228

neXtProt AC: NX_Q52WX2

UniProt: Q52WX2
Chr Location

16p12.1; chr16:28258681-28323849 (+) GRCh38

MGI Vertebrate Homology

Sbk1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SBK1
Protein SuperFamily

Ser/Thr_PK_Sbk1
Gene Tree

Sbk1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

4
Targeted

5
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

27
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

822
Tissues

106
cDNA Data

343
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sbk1

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All Sequences

63
RefSeq

8
UniProt

4
CCDS

CCDS21824.1

Ensembl

ENSMUSG00000042978 (Evidence)
NCBI Gene

104175

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042978	Ensembl Gene Model \| MGI Sequence Detail	46155	C57BL/6J	± kb
transcript	ENSMUST00000239081	Ensembl \| MGI Sequence Detail	1512	Not Applicable
polypeptide	ENSMUSP00000159131	Ensembl \| MGI Sequence Detail	503	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014475 serine/threonine-protein kinase SBK1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR016234 Serine/threonine-protein kinase, Sbk1

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All nucleic 345

Genomic 1

cDNA 343

Primer pair 1

Microarray probesets 4

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 11
Earliest

J:69266 Nara K, et al., Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain. Eur J Biochem. 2001 May;268(9):2642-51
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sbk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69000	Chr7:125847514-125847530 (+)	-512 bp
Tssr69001	Chr7:125847536-125847547 (+)	-492 bp
Tssr69002	Chr7:125871585-125871596 (+)	23,557 bp
Tssr69003	Chr7:125871600-125871615 (+)	23,574 bp
Tssr69004	Chr7:125871616-125871627 (+)	23,588 bp
Tssr69005	Chr7:125871635-125871646 (+)	23,607 bp
Tssr69006	Chr7:125871647-125871664 (+)	23,622 bp
Tssr69007	Chr7:125871678-125871696 (+)	23,653 bp
Tssr69008	Chr7:125871698-125871759 (+)	23,695 bp
Tssr69009	Chr7:125871761-125871781 (+)	23,737 bp
Tssr69010	Chr7:125871956-125871967 (+)	23,928 bp
Tssr69011	Chr7:125872019-125872030 (+)	23,991 bp
Tssr69012	Chr7:125891645-125891660 (+)	43,619 bp
Tssr69013	Chr7:125892579-125892585 (+)	44,548 bp
Tssr69014	Chr7:125892989-125893003 (+)	44,962 bp
Tssr69015	Chr7:125893163-125893173 (+)	45,134 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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