Camta2 MGI Mouse Gene Detail - MGI:2135957 - calmodulin binding transcription activator 2

Symbol

Camta2
Name

calmodulin binding transcription activator 2
Synonyms

Kiaa0909-hp, mKIAA0909

Feature Type

protein coding gene
IDs

MGI:2135957
NCBI Gene: 216874
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr11:70560289-70578931 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 43.21 cM
Mapping Data

1 experiment

SNPs within 2kb

217 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2135957	protein coding gene	Chr11:70560288-70578966 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018612	protein coding gene	Chr11:71212910-71235475 (-)
A/J	MGP_AJ_G0018580	protein coding gene	Chr11:68524034-68542654 (-)
AKR/J	MGP_AKRJ_G0018549	protein coding gene	Chr11:70581228-70601133 (-)
BALB/cJ	MGP_BALBcJ_G0018552	protein coding gene	Chr11:68833217-68851840 (-)
C3H/HeJ	MGP_C3HHeJ_G0018365	protein coding gene	Chr11:70599903-70619002 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019003	protein coding gene	Chr11:73372810-73393027 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016648	protein coding gene	Chr11:65431611-65449955 (-)
CAST/EiJ	MGP_CASTEiJ_G0017920	protein coding gene	Chr11:70872617-70892487 (-)
CBA/J	MGP_CBAJ_G0018337	protein coding gene	Chr11:76676931-76695523 (-)
DBA/2J	MGP_DBA2J_G0018447	protein coding gene	Chr11:68097231-68115895 (-)
FVB/NJ	MGP_FVBNJ_G0018437	protein coding gene	Chr11:67737975-67757683 (-)
LP/J	MGP_LPJ_G0018517	protein coding gene	Chr11:71794990-71813619 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018460	protein coding gene	Chr11:77228554-77247208 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019045	protein coding gene	Chr11:70840108-70858709 (-)
PWK/PhJ	MGP_PWKPhJ_G0017694	protein coding gene	Chr11:68744423-68763202 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017484	protein coding gene	Chr11:70656887-70676858 (-)
WSB/EiJ	MGP_WSBEiJ_G0017974	protein coding gene	Chr11:70498441-70519959 (-)

Human Ortholog

CAMTA2, calmodulin binding transcription activator 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CAMTA2, calmodulin binding transcription activator 2
Links

HGNC:18807

NCBI Gene ID: 23125

neXtProt AC: NX_O94983

UniProt: O94983
Chr Location

17p13.2; chr17:4967992-4987675 (-) GRCh38

MGI Vertebrate Homology

Camta2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CAMTA2
Gene Tree

Camta2

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Targeted

6
Transgenic

1
Genomic Mutations

2 involving Camta2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable, fertile and free of obvious cardiac defects, but show reduced pathophysiologic cardiac hypertrophy in response to diverse stress stimuli.

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

46
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase camta2

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All Sequences

91
RefSeq

28
UniProt

4
CCDS

CCDS24963.1, CCDS56786.1, CCDS56787.1, CCDS56788.1

Ensembl

ENSMUSG00000040712 (Evidence)
NCBI Gene

216874

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040712	Ensembl Gene Model \| MGI Sequence Detail	18643	C57BL/6J	± kb
transcript	ENSMUST00000036299	Ensembl \| MGI Sequence Detail	4495	Not Applicable
polypeptide	ENSMUSP00000043792	Ensembl \| MGI Sequence Detail	1208	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005001 calmodulin-binding transcription activator 2

(term hierarchy)
InterPro Domains

IPR036770 Ankyrin repeat-containing domain superfamily

IPR005559 CG-1 DNA-binding domain

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR002909 IPT domain

IPR000048 IQ motif, EF-hand binding site

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 15

Genomic 1

cDNA 14

Microarray probesets 4

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:242946 Darlington TM, et al., Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling. Genes Brain Behav. 2016 Jun;15(5):474-90

TSS for Camta2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109036	Chr11:70578923-70578958 (-)	-10 bp
Tssr109035	Chr11:70578886-70578896 (-)	40 bp
Tssr109034	Chr11:70578743-70578807 (-)	156 bp
Tssr109033	Chr11:70578040-70578076 (-)	873 bp
Tssr109032	Chr11:70577725-70577784 (-)	1,176 bp
Tssr109031	Chr11:70576961-70576979 (-)	1,961 bp
Tssr109030	Chr11:70574516-70574527 (-)	4,409 bp
Tssr109029	Chr11:70574475-70574499 (-)	4,444 bp
Tssr109028	Chr11:70574444-70574466 (-)	4,476 bp
Tssr109027	Chr11:70574148-70574223 (-)	4,745 bp
Tssr109026	Chr11:70572592-70572600 (-)	6,335 bp
Tssr109025	Chr11:70572475-70572499 (-)	6,444 bp
Tssr109024	Chr11:70566413-70566417 (-)	12,516 bp
Tssr109023	Chr11:70562424-70562434 (-)	16,502 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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