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Lyve1 Gene Detail
Summary
  • Symbol
    Lyve1
  • Name
    lymphatic vessel endothelial hyaluronan receptor 1
  • Synonyms
    1200012G08Rik, lymphatic vessel endothelial HA receptor-1, Lyve-1, Xlkd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136348
    NCBI Gene: 114332
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:110449814-110462160 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 57.89 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    354 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136348
 protein coding gene Chr7:110449814-110462446 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032861
 protein coding gene Chr7:114356259-114370023 (-)
A/J MGP_AJ_G0032844
 protein coding gene Chr7:111527791-111540132 (-)
AKR/J MGP_AKRJ_G0032776
 protein coding gene Chr7:114313124-114326561 (-)
BALB/cJ MGP_BALBcJ_G0032849
 protein coding gene Chr7:111207886-111220219 (-)
C3H/HeJ MGP_C3HHeJ_G0032559
 protein coding gene Chr7:114326383-114339237 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033355
 protein coding gene Chr7:119087022-119099639 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030327
 protein coding gene Chr7:113132968-113145652 (-)
CAST/EiJ MGP_CASTEiJ_G0031887
 protein coding gene Chr7:105913411-105925748 (-)
CBA/J MGP_CBAJ_G0032532
 protein coding gene Chr7:122974758-122989564 (-)
DBA/2J MGP_DBA2J_G0032684
 protein coding gene Chr7:109610268-109622562 (-)
FVB/NJ MGP_FVBNJ_G0032637
 protein coding gene Chr7:109467186-109479517 (-)
LP/J MGP_LPJ_G0032778
 protein coding gene Chr7:115874993-115887230 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032669
 protein coding gene Chr7:124637324-124649651 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033375
 protein coding gene Chr7:113335246-113347591 (-)
PWK/PhJ MGP_PWKPhJ_G0031594
 protein coding gene Chr7:102452767-102465178 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031442
 protein coding gene Chr7:100084007-100096235 (-)
WSB/EiJ MGP_WSBEiJ_G0032000
 protein coding gene Chr7:114189166-114201496 (-)



Homology
more
  • Human Ortholog
    LYVE1, lymphatic vessel endothelial hyaluronan receptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LYVE1, lymphatic vessel endothelial hyaluronan receptor 1
  • Synonyms
    CRSBP-1, HAR, LYVE-1, XLKD1
  • Links
    NCBI Gene ID: 10894
    neXtProt AC: NX_Q9Y5Y7
    UniProt: Q9Y5Y7

  • Chr Location
    11p15.4; chr11:10556966-10611689 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    2 images
    90 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one allele display enlarged lymphatic vessels and increased interstitial-lymphatic flow. However, mice homozygous for a second allele do not display any abnormalities in the lymphatic system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1831
  • Tissues
    277
  • cDNA Data
    41
  • Literature Summary
    294
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 114332 NCBI Gene Model | MGI Sequence Detail 12347 C57BL/6J ±  kb
    transcript NM_053247 RefSeq | MGI Sequence Detail 2607 C57BL/6  
    polypeptide Q8BHC0 UniProt | EBI | MGI Sequence Detail 318 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 41
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1914711
    References
    more
    • Summaries
      All 405
      Developmental Gene Expression 294
      Gene Ontology 7
      Phenotypes 90
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:351095 Brouillard P, et al., Loss-of-function mutations of the TIE1 receptor tyrosine kinase cause late-onset primary lymphedema. J Clin Invest. 2024 May 30;134(14)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory