Cdc42bpb MGI Mouse Gene Detail - MGI:2136459 - CDC42 binding protein kinase beta

Symbol

Cdc42bpb
Name

CDC42 binding protein kinase beta
Synonyms

DMPK-like

Feature Type

protein coding gene
IDs

MGI:2136459
NCBI Gene: 217866
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:111259410-111344152 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 60.94 cM
Mapping Data

2 experiments

SNPs within 2kb

2796 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2136459	protein coding gene	Chr12:111259406-111347985 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020130	protein coding gene	Chr12:113670297-113765330 (-)
A/J	MGP_AJ_G0020086	protein coding gene	Chr12:109304686-109390504 (-)
AKR/J	MGP_AKRJ_G0020061	protein coding gene	Chr12:112435810-112526891 (-)
BALB/cJ	MGP_BALBcJ_G0020071	protein coding gene	Chr12:109720658-109806504 (-)
C3H/HeJ	MGP_C3HHeJ_G0019873	protein coding gene	Chr12:112939875-113026594 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020516	protein coding gene	Chr12:117194608-117289127 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018129	protein coding gene	Chr12:105749239-105833251 (-)
CAST/EiJ	MGP_CASTEiJ_G0019414	protein coding gene	Chr12:107783996-107852492 (-)
CBA/J	MGP_CBAJ_G0019840	protein coding gene	Chr12:121682007-121768748 (-)
DBA/2J	MGP_DBA2J_G0019957	protein coding gene	Chr12:108788278-108873863 (-)
FVB/NJ	MGP_FVBNJ_G0019942	protein coding gene	Chr12:107581357-107670188 (-)
LP/J	MGP_LPJ_G0020032	protein coding gene	Chr12:113483648-113581064 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019980	protein coding gene	Chr12:124802330-124890271 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020545	protein coding gene	Chr12:111942403-112031836 (-)
PWK/PhJ	MGP_PWKPhJ_G0019175	protein coding gene	Chr12:103420125-103509751 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018978	protein coding gene	Chr12:106101906-106188613 (-)
WSB/EiJ	MGP_WSBEiJ_G0019473	protein coding gene	Chr12:112870725-112958034 (-)

Human Ortholog

CDC42BPB, CDC42 binding protein kinase beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDC42BPB, CDC42 binding protein kinase beta
Synonyms

CHOCNS, MRCKB
Links

HGNC:1738

NCBI Gene ID: 9578

neXtProt AC: NX_Q9Y5S2

UniProt: Q9Y5S2
Chr Location

14q32.32; chr14:102932380-103057549 (-) GRCh38

MGI Vertebrate Homology

Cdc42bpb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDC42BPB
Gene Tree

Cdc42bpb

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

9
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available

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All GO Annotations

59
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

1
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDC42BPB

Xenbase cdc42bpb

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All Sequences

56
RefSeq

7
UniProt

5
CCDS

CCDS26176.1

Ensembl

ENSMUSG00000021279 (Evidence)
NCBI Gene

217866

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021279	Ensembl Gene Model \| MGI Sequence Detail	84743	C57BL/6J	± kb
transcript	ENSMUST00000041965	Ensembl \| MGI Sequence Detail	6714	Not Applicable
polypeptide	ENSMUSP00000042565	Ensembl \| MGI Sequence Detail	1713	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005206 serine/threonine-protein kinase MRCK beta

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR046349 C1-like domain superfamily

IPR001180 Citron homology (CNH) domain

IPR000095 CRIB domain

IPR036936 CRIB domain superfamily

IPR020454 Diacylglycerol/phorbol-ester binding

IPR031597 KELK-motif containing domain

IPR014930 Myotonic dystrophy protein kinase, coiled coil

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR017441 Protein kinase, ATP binding site

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050839 Rho-associated Serine/Threonine Kinase

IPR008271 Serine/threonine-protein kinase, active site

IPR042718 Serine/threonine-protein kinase MRCK beta, catalytic domain
GlyGen

Q7TT50 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 5

Genomic 4

cDNA 1

Microarray probesets 5

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 11

Phenotypes 8
Earliest

J:68615 Kalantry S, et al., The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain. Nat Genet. 2001 Apr;27(4):412-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cdc42bpb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117814	Chr12:111344220-111344233 (-)	-75 bp
Tssr117813	Chr12:111344139-111344153 (-)	6 bp
Tssr117812	Chr12:111344038-111344130 (-)	68 bp
Tssr117811	Chr12:111344019-111344030 (-)	127 bp
Tssr117810	Chr12:111343872-111343936 (-)	248 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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