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Pcdhb1 Gene Detail
Summary
  • Symbol
    Pcdhb1
  • Name
    protocadherin beta 1
  • Synonyms
    PcdhbA
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136730
    NCBI Gene: 93872
  • Member of
    Pcdhb cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr18:37397991-37400578 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.46 cM, cytoband B3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136730
 protein coding gene Chr18:37397897-37400578 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024310
 protein coding gene Chr18:35658430-35661017 (+)
A/J MGP_AJ_G0024277
 protein coding gene Chr18:34456444-34459031 (+)
AKR/J MGP_AKRJ_G0024245
 protein coding gene Chr18:35401993-35404580 (+)
BALB/cJ MGP_BALBcJ_G0024276
 protein coding gene Chr18:34485396-34487983 (+)
C3H/HeJ MGP_C3HHeJ_G0024043
 protein coding gene Chr18:35460998-35463585 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024718
 protein coding gene Chr18:36953896-36956483 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022157
 protein coding gene Chr18:34513084-34515671 (+)
CAST/EiJ MGP_CASTEiJ_G0023518
 protein coding gene Chr18:35429912-35432499 (+)
CBA/J MGP_CBAJ_G0024012
 protein coding gene Chr18:38041490-38044077 (+)
DBA/2J MGP_DBA2J_G0024142
 protein coding gene Chr18:34040408-34042995 (+)
FVB/NJ MGP_FVBNJ_G0024109
 protein coding gene Chr18:33767856-33770443 (+)
LP/J MGP_LPJ_G0024226
 protein coding gene Chr18:35753407-35755994 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024139
 protein coding gene Chr18:39305860-39308447 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024767
 protein coding gene Chr18:35265424-35268011 (+)
PWK/PhJ MGP_PWKPhJ_G0023262
 protein coding gene Chr18:34280088-34282675 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023068
 protein coding gene Chr18:35502432-35505019 (+)
WSB/EiJ MGP_WSBEiJ_G0023581
 protein coding gene Chr18:35161134-35163721 (+)



Homology
more
  • Human Ortholog
    PCDHB1, protocadherin beta 1
  • Vertebrate Orthologs
    13
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCDHB1, protocadherin beta 1
  • Synonyms
    PCDH-BETA1
  • Links
    NCBI Gene ID: 29930
    neXtProt AC: NX_Q9Y5F3
    UniProt: Q9Y5F3

  • Chr Location
    5q31.3; chr5:141051374-141059346 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    25
  • cDNA Data
    4
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051663 Ensembl Gene Model | MGI Sequence Detail 2588 C57BL/6J ±  kb
transcript ENSMUST00000052366 Ensembl | MGI Sequence Detail 2588 Not Applicable  
polypeptide ENSMUSP00000057519 Ensembl | MGI Sequence Detail 818 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • PDB
    4ZPL
  • InterPro Domains
    IPR020894 Cadherin conserved site
    IPR032455 Cadherin, cytoplasmic C-terminal domain
    IPR002126 Cadherin-like
    IPR015919 Cadherin-like superfamily
    IPR013164 Cadherin, N-terminal
    IPR050174 Protocadherin/Cadherin-related Cell Adhesion
  • GlyGen
    Q91Y08 4 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 7
    cDNA 4
    Primer pair 3

    Microarray probesets 2
References
more
  • Summaries
    All 23
    Developmental Gene Expression 3
    Gene Ontology 1
    Phenotypes 5
  • Earliest
    J:67989 Wu Q, et al., Comparative dna sequence analysis of mouse and human protocadherin gene clusters. Genome Res. 2001 Mar;11(3):389-404
  • Latest
    J:332241 Kobayashi H, et al., Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality. iScience. 2023 Jan 20;26(1):105766
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory