BC004004 MGI Mouse Gene Detail - MGI:2136782

Symbol

BC004004
Name

cDNA sequence BC004004
Synonyms

2400006G15Rik, MGC:7550

Feature Type

protein coding gene
IDs

MGI:2136782
NCBI Gene: 80748
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr17:29487762-29521862 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 15.17 cM, cytoband B1
Mapping Data

3 experiments

SNPs within 2kb

1216 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2136782	protein coding gene	Chr17:29487762-29533039 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023461	protein coding gene	Chr17:28783609-28823148 (+)
A/J	MGP_AJ_G0023419	protein coding gene	Chr17:27795977-27837361 (+)
AKR/J	MGP_AKRJ_G0023384	protein coding gene	Chr17:28028959-28065523 (+)
BALB/cJ	MGP_BALBcJ_G0023424	protein coding gene	Chr17:28063430-28098067 (+)
C3H/HeJ	MGP_C3HHeJ_G0023185	protein coding gene	Chr17:28414174-28456678 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023866	protein coding gene	Chr17:29933040-29967837 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021341	protein coding gene	Chr17:25125575-25161906 (+)
CAST/EiJ	MGP_CASTEiJ_G0022686	protein coding gene	Chr17:28394090-28432081 (+)
CBA/J	MGP_CBAJ_G0023160	protein coding gene	Chr17:31036460-31075454 (+)
DBA/2J	MGP_DBA2J_G0023290	protein coding gene	Chr17:27327015-27360703 (+)
FVB/NJ	MGP_FVBNJ_G0023260	protein coding gene	Chr17:27165435-27201613 (+)
LP/J	MGP_LPJ_G0023368	protein coding gene	Chr17:29035952-29075805 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023278	protein coding gene	Chr17:30384853-30422895 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023908	protein coding gene	Chr17:28495391-28533203 (+)
PWK/PhJ	MGP_PWKPhJ_G0022436	protein coding gene	Chr17:26167121-26204030 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022254	protein coding gene	Chr17:26476568-26510399 (+)
WSB/EiJ	MGP_WSBEiJ_G0022748	protein coding gene	Chr17:28450030-28485288 (+)

Human Ortholog

C6orf89, chromosome 6 open reading frame 89

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C6orf89, chromosome 6 open reading frame 89
Synonyms

BRAP, PS1TP5TP1
Links

HGNC:21114

NCBI Gene ID: 221477

neXtProt AC: NX_Q6UWU4

UniProt: Q6UWU4
Chr Location

6p21.2; chr6:36871844-36928964 (+) GRCh38

MGI Vertebrate Homology

BC004004 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: C6orf89
Gene Tree

BC004004

less

Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

79
Endonuclease-mediated

2
Gene trapped

74
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

46 strains or lines available

Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested. Another knock-out allele shows attenuation of pulmonary injury and fibrosis and enhanced autophagy in the lungs.

less

All GO Annotations

24
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

97

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

113
RefSeq

8
UniProt

16
CCDS

CCDS28594.1

Ensembl

ENSMUSG00000052712 (Evidence)
NCBI Gene

80748

			Length	Strain/Species	Flank
genomic	80748	NCBI Gene Model \| MGI Sequence Detail	34101	C57BL/6J	± kb
transcript	NM_030561	RefSeq \| MGI Sequence Detail	2809	C57BL/6
polypeptide	Q99KU6	UniProt \| EBI \| MGI Sequence Detail	348	Not Applicable

less

UniProt

16 Sequences
Protein Ontology

PR:000059874 bombesin receptor-activated protein C6orf89

(term hierarchy)
InterPro Domains

IPR038757 Bombesin receptor-activated protein

less

All nucleic 97

cDNA 97

Microarray probesets 6

less

MGI:1916975

Summaries

All 35

Gene Ontology 4

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:332577 Yao X, et al., Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice. Stress. 2023 Jan;26(1):1-14

TSS for BC004004:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143518	Chr17:29487792-29487803 (+)	36 bp
Tssr143519	Chr17:29487865-29487876 (+)	109 bp
Tssr143520	Chr17:29487882-29487948 (+)	153 bp
Tssr143521	Chr17:29493052-29493103 (+)	5,316 bp
Tssr143522	Chr17:29493113-29493136 (+)	5,363 bp
Tssr143523	Chr17:29493159-29493177 (+)	5,406 bp
Tssr143524	Chr17:29493194-29493203 (+)	5,437 bp
Tssr143525	Chr17:29513013-29513034 (+)	25,262 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24