Morc3 MGI Mouse Gene Detail - MGI:2136841

Symbol

Morc3
Name

microrchidia 3
Synonyms

1110051N18Rik, 1110051N18Rik, D16Jhu32e, Nxp-2, Zcwcc3

Feature Type

protein coding gene
IDs

MGI:2136841
NCBI Gene: 338467
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr16:93629009-93672961 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 54.88 cM
Mapping Data

3 experiments

SNPs within 2kb

1172 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2136841	protein coding gene	Chr16:93629009-93672964 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023064	protein coding gene	Chr16:95039949-95087267 (+)
A/J	MGP_AJ_G0023032	protein coding gene	Chr16:90578966-90622989 (+)
AKR/J	MGP_AKRJ_G0023002	protein coding gene	Chr16:93357958-93404072 (+)
BALB/cJ	MGP_BALBcJ_G0023034	protein coding gene	Chr16:91102683-91146634 (+)
C3H/HeJ	MGP_C3HHeJ_G0022795	protein coding gene	Chr16:93860348-93909176 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023481	protein coding gene	Chr16:98054401-98102515 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020983	protein coding gene	Chr16:88427969-88470059 (+)
CAST/EiJ	MGP_CASTEiJ_G0022314	protein coding gene	Chr16:94591082-94639196 (+)
CBA/J	MGP_CBAJ_G0022764	protein coding gene	Chr16:102303174-102351889 (+)
DBA/2J	MGP_DBA2J_G0022898	protein coding gene	Chr16:90466373-90510620 (+)
FVB/NJ	MGP_FVBNJ_G0022872	protein coding gene	Chr16:89623700-89667464 (+)
LP/J	MGP_LPJ_G0022968	protein coding gene	Chr16:94705569-94749623 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022893	protein coding gene	Chr16:106686968-106733225 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023499	protein coding gene	Chr16:93859035-93904279 (+)
PWK/PhJ	MGP_PWKPhJ_G0022059	protein coding gene	Chr16:90712622-90760716 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021889	protein coding gene	Chr16:93400836-93446857 (+)
WSB/EiJ	MGP_WSBEiJ_G0022365	protein coding gene	Chr16:94105482-94153235 (+)

Human Ortholog

MORC3, MORC family CW-type zinc finger 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MORC3, MORC family CW-type zinc finger 3
Synonyms

NXP2, ZCW5, ZCWCC3
Links

HGNC:23572

NCBI Gene ID: 23515

neXtProt AC: NX_Q14149

UniProt: Q14149
Chr Location

21q22.12; chr21:36320189-36386148 (+) GRCh38

MGI Vertebrate Homology

Morc3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MORC3
Gene Tree

Morc3

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References

6 with disease annotations

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
101 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

44
Chemically induced (ENU)

1
Endonuclease-mediated

1
Gene trapped

26
Spontaneous

1
Targeted

14
Genomic Mutations

11 involving Morc3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

80 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele die at or within a day of birth.

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All GO Annotations

34
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

772
Tissues

64
cDNA Data

15
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase LOC105945150, morc3

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All Sequences

56
RefSeq

4
UniProt

4
CCDS

CCDS79490.1

Ensembl

ENSMUSG00000039456 (Evidence)
NCBI Gene

338467

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039456	Ensembl Gene Model \| MGI Sequence Detail	43953	C57BL/6J	± kb
transcript	ENSMUST00000202261	Ensembl \| MGI Sequence Detail	4179	Not Applicable
polypeptide	ENSMUSP00000144369	Ensembl \| MGI Sequence Detail	942	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000030946 MORC family CW-type zinc finger protein 3

(term hierarchy)
PDB

5IX1, 5IX2
InterPro Domains

IPR036890 Histidine kinase/HSP90-like ATPase superfamily

IPR045261 MICRORCHIDIA ATPase family

IPR041006 Morc, S5 domain 2-like

IPR011124 Zinc finger, CW-type
GlyGen

F7BJB9 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 19

cDNA 16

Primer pair 2

Other 1

Microarray probesets 4

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MGI:1916059, MGI:2146436, MGI:2652138

Summaries

All 131

Developmental Gene Expression 3

Diseases 6

Gene Ontology 8

Phenotypes 101
Earliest

J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Morc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139526	Chr16:93629109-93629196 (+)	144 bp
Tssr139527	Chr16:93630159-93630165 (+)	1,153 bp
Tssr139528	Chr16:93661335-93661339 (+)	32,328 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24