P2rx5 MGI Mouse Gene Detail - MGI:2137026 - purinergic receptor P2X, ligand-gated ion channel, 5

Symbol

P2rx5
Name

purinergic receptor P2X, ligand-gated ion channel, 5
Synonyms

P2X5

Feature Type

protein coding gene
IDs

MGI:2137026
NCBI Gene: 94045
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:73051247-73063511 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.25 cM, cytoband B5
Mapping Data

1 experiment

SNPs within 2kb

145 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2137026	protein coding gene	Chr11:73029164-73063511 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018653	protein coding gene	Chr11:73839396-73851658 (+)
A/J	MGP_AJ_G0018621	protein coding gene	Chr11:71067048-71079201 (+)
AKR/J	MGP_AKRJ_G0018590	protein coding gene	Chr11:73238023-73250283 (+)
BALB/cJ	MGP_BALBcJ_G0018593	protein coding gene	Chr11:71368274-71380540 (+)
C3H/HeJ	MGP_C3HHeJ_G0018406	protein coding gene	Chr11:73190105-73202367 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019044	protein coding gene	Chr11:76088468-76100732 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016687	protein coding gene	Chr11:67872417-67885394 (+)
CAST/EiJ	MGP_CASTEiJ_G0017961	protein coding gene	Chr11:73573377-73585633 (+)
CBA/J	MGP_CBAJ_G0018378	protein coding gene	Chr11:79438907-79451154 (+)
DBA/2J	MGP_DBA2J_G0018487	protein coding gene	Chr11:70693837-70706033 (+)
FVB/NJ	MGP_FVBNJ_G0018478	protein coding gene	Chr11:70241283-70253547 (+)
LP/J	MGP_LPJ_G0018558	protein coding gene	Chr11:74354085-74368532 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018501	protein coding gene	Chr11:79951750-79964365 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019086	protein coding gene	Chr11:73421138-73433404 (+)
PWK/PhJ	MGP_PWKPhJ_G0017734	protein coding gene	Chr11:71335855-71348530 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017524	protein coding gene	Chr11:73137668-73149677 (+)
WSB/EiJ	MGP_WSBEiJ_G0018015	protein coding gene	Chr11:73168473-73181054 (+)

Human Ortholog

P2RX5, purinergic receptor P2X 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

P2RX5, purinergic receptor P2X 5
Synonyms

LRH-1, P2X5, P2X5R
Links

HGNC:8536

NCBI Gene ID: 5026

neXtProt AC: NX_Q93086

UniProt: Q93086
Chr Location

17p13.2; chr17:3672199-3696240 (-) GRCh38

MGI Vertebrate Homology

P2rx5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: P2RX5
Protein SuperFamily

P2X_purinoceptor
Gene Tree

P2rx5

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

5
Genomic Mutations

2 involving P2rx5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available

Homozygous mutant mice exhibit decreased peripheral blood CD8+ lymphocytes and elevated NK cells. Impaired learning/memory during trace aversive conditioning and increased exploratory behavior during open field testing is also seen.

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All GO Annotations

20
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

756
Tissues

42
cDNA Data

7
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase p2rx5

ZFIN p2rx5

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All Sequences

51
RefSeq

12
UniProt

5
CCDS

CCDS24998.1

Ensembl

ENSMUSG00000005950 (Evidence)
NCBI Gene

94045

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005950	Ensembl Gene Model \| MGI Sequence Detail	12265	C57BL/6J	± kb
transcript	ENSMUST00000006104	Ensembl \| MGI Sequence Detail	2395	Not Applicable
polypeptide	ENSMUSP00000006104	Ensembl \| MGI Sequence Detail	455	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR003048 P2X5 purinoceptor

IPR001429 P2X purinoreceptor

IPR027309 P2X purinoreceptor extracellular domain superfamily
GlyGen

Q91VE2 3 sites, 1 N-linked glycan (1 site)

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All nucleic 9

Genomic 1

cDNA 7

Primer pair 1

Microarray probesets 2

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for P2rx5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102884	Chr11:73051134-73051167 (+)	-96 bp
Tssr102885	Chr11:73051208-73051221 (+)	-32 bp
Tssr102886	Chr11:73051229-73051246 (+)	-9 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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