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Eefsec Gene Detail
Summary
  • Symbol
    Eefsec
  • Name
    eukaryotic elongation factor, selenocysteine-tRNA-specific
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137092
    NCBI Gene: 65967
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr6:88234318-88423489 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 39.32 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3298 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137092
 protein coding gene Chr6:88234316-88423521 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031009
 protein coding gene Chr6:89643754-89844271 (-)
A/J MGP_AJ_G0030975
 protein coding gene Chr6:86191633-86386560 (-)
AKR/J MGP_AKRJ_G0030906
 protein coding gene Chr6:88678267-88873873 (-)
BALB/cJ MGP_BALBcJ_G0030988
 protein coding gene Chr6:86188967-86382228 (-)
C3H/HeJ MGP_C3HHeJ_G0030722
 protein coding gene Chr6:95581658-95781818 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031445
 protein coding gene Chr6:92070025-92269379 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028627
 protein coding gene Chr6:84354308-84546197 (-)
CAST/EiJ MGP_CASTEiJ_G0030097
 protein coding gene Chr6:88767397-88970243 (-)
CBA/J MGP_CBAJ_G0030672
 protein coding gene Chr6:95608684-95811876 (-)
DBA/2J MGP_DBA2J_G0030828
 protein coding gene Chr6:85485287-85676159 (-)
FVB/NJ MGP_FVBNJ_G0030781
 protein coding gene Chr6:84676784-84868441 (-)
LP/J MGP_LPJ_G0030905
 protein coding gene Chr6:89683251-89882440 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030814
 protein coding gene Chr6:99718482-99916857 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031472
 protein coding gene Chr6:88530719-88729255 (-)
PWK/PhJ MGP_PWKPhJ_G0029812
 protein coding gene Chr6:84457569-84651043 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029640
 protein coding gene Chr6:87342177-87537275 (-)
WSB/EiJ MGP_WSBEiJ_G0030178
 protein coding gene Chr6:88982090-89178309 (-)



Homology
more
  • Human Ortholog
    EEFSEC, eukaryotic elongation factor, selenocysteine-tRNA specific
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EEFSEC, eukaryotic elongation factor, selenocysteine-tRNA specific
  • Synonyms
    EFSEC, SELB
  • Links
    NCBI Gene ID: 60678
    neXtProt AC: NX_P57772
    UniProt: P57772

  • Chr Location
    3q21.3; chr3:128153481-128426223 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    19
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    39
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 65967 NCBI Gene Model | MGI Sequence Detail 189172 C57BL/6J ±  kb
transcript NR_177255 RefSeq | MGI Sequence Detail 2749 C57BL/6  
polypeptide Q9JHW4 UniProt | EBI | MGI Sequence Detail 583 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000006911 selenocysteine-specific elongation factor
    (term hierarchy)
  • EC
    3.6.5.-
  • InterPro Domains
    IPR050055 Elongation factor Tu GTPase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR049393 Selenocysteine-specific elongation factor, 3rd domain
    IPR049394 Selenocysteine-specific elongation factor, C-terminal RIFT domain
    IPR005225 Small GTP-binding protein domain
    IPR000795 Translational (tr)-type GTP-binding domain
    IPR004161 Translation elongation factor EFTu-like, domain 2
    IPR009000 Translation protein, beta-barrel domain superfamily
Molecular
Reagents
less
  • All nucleic 39
    cDNA 39

    Microarray probesets 3
References
more
  • Summaries
    All 39
    Gene Ontology 11
    Phenotypes 11
  • Earliest
    J:63958 Tujebajeva RM, et al., Decoding apparatus for eukaryotic selenocysteine insertion. EMBO Rep. 2000;1(2):158-163
  • Latest
    J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory