Baiap2 MGI Mouse Gene Detail - MGI:2137336 - brain-specific angiogenesis inhibitor 1-associated protein 2

Symbol

Baiap2
Name

brain-specific angiogenesis inhibitor 1-associated protein 2
Synonyms

IRSp53

Feature Type

protein coding gene
IDs

MGI:2137336
NCBI Gene: 108100
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:119833762-119897608 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 83.96 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

1070 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2137336	protein coding gene	Chr11:119833589-119897608 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019487	protein coding gene	Chr11:124370038-124437100 (+)
A/J	MGP_AJ_G0019455	protein coding gene	Chr11:118844647-118909182 (+)
AKR/J	MGP_AKRJ_G0019425	protein coding gene	Chr11:122424086-122488610 (+)
BALB/cJ	MGP_BALBcJ_G0019430	protein coding gene	Chr11:119200448-119264787 (+)
C3H/HeJ	MGP_C3HHeJ_G0019236	protein coding gene	Chr11:122744068-122809334 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019879	protein coding gene	Chr11:128135758-128204106 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017504	protein coding gene	Chr11:115846383-115912099 (+)
CAST/EiJ	MGP_CASTEiJ_G0018790	protein coding gene	Chr11:124219027-124285878 (+)
CBA/J	MGP_CBAJ_G0019207	protein coding gene	Chr11:133147966-133220040 (+)
DBA/2J	MGP_DBA2J_G0019319	protein coding gene	Chr11:118211178-118274994 (+)
FVB/NJ	MGP_FVBNJ_G0019311	protein coding gene	Chr11:117895989-117963515 (+)
LP/J	MGP_LPJ_G0019391	protein coding gene	Chr11:124682127-124745976 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019344	protein coding gene	Chr11:132022146-132088114 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019918	protein coding gene	Chr11:123103094-123169854 (+)
PWK/PhJ	MGP_PWKPhJ_G0018556	protein coding gene	Chr11:119636737-119701428 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018348	protein coding gene	Chr11:122870149-122934046 (+)
WSB/EiJ	MGP_WSBEiJ_G0018842	protein coding gene	Chr11:123096922-123165030 (+)

Human Ortholog

BAIAP2, BAR/IMD domain containing adaptor protein 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BAIAP2, BAR/IMD domain containing adaptor protein 2
Synonyms

BAP2, FLAF3, IRSP53, WAML
Links

HGNC:947

NCBI Gene ID: 10458

neXtProt AC: NX_Q9UQB8

UniProt: Q9UQB8
Chr Location

17q25.3; chr17:81035122-81117434 (+) GRCh38

MGI Vertebrate Homology

Baiap2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BAIAP2
Gene Tree

Baiap2

Diseases

3 with human BAIAP2 associations

				Human Disease	Mouse Models
				attention deficit hyperactivity disorder IDs attention deficit hyperactivity disorder DOID:1094 DOID:1093 EFO:0003888 ICD9CM:314.8 MESH:D001289 OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312 UMLS_CUI:C0041671
				autism spectrum disorder IDs autism spectrum disorder DOID:0060041 MESH:D000067877
				Gilles de la Tourette syndrome IDs Gilles de la Tourette syndrome DOID:11119 EFO:0004895 ICD10CM:F95.2 ICD9CM:307.23 MESH:D005879 NCI:C35078 OMIM:137580 UMLS_CUI:C0040517

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

40 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

2
Gene trapped

7
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a knock-out allele show mid to late gestation lethality, developmental delay, oligodactyly, subcutaneous edema, and severely impaired cardiac and placental development. Adult homozygotes fail to regulate synaptic plasticity and exhibit hippocampus-associated learning deficits.

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All GO Annotations

89
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

890
Tissues

87
cDNA Data

113
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase baiap2

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All Sequences

77
RefSeq

16
UniProt

4
CCDS

CCDS25722.1, CCDS25723.1, CCDS25724.1

Ensembl

ENSMUSG00000025372 (Evidence)
NCBI Gene

108100

			Length	Strain/Species	Flank
genomic	108100	NCBI Gene Model \| MGI Sequence Detail	63847	C57BL/6J	± kb
transcript	NM_130862	RefSeq \| MGI Sequence Detail	3186	C57BL/6
polypeptide	Q8BKX1	UniProt \| EBI \| MGI Sequence Detail	535	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004632 brain-specific angiogenesis inhibitor 1-associated protein 2

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR030128 I-BAR domain containing protein IRSp53, Inverse-Bin/Amphiphysin/Rvs domain

IPR027681 I-BAR domain containing protein IRSp53/IRTKS/Pinkbar

IPR013606 IMD/I-BAR domain

IPR035594 IRSp53, SH3 domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

Q8BKX1 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 116

cDNA 113

Primer pair 2

Other 1

Microarray probesets 8

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MGI:2144701

Summaries

All 72

Developmental Gene Expression 11

Gene Ontology 18

Phenotypes 22
Earliest

J:62164 Fujiwara T, et al., Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2. Biochem Biophys Res Commun. 2000 May 19;271(3):626-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Baiap2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106263	Chr11:119833908-119833925 (+)	155 bp
Tssr106264	Chr11:119887806-119887832 (+)	54,057 bp
Tssr106265	Chr11:119889934-119889950 (+)	56,180 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24