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Med15 Gene Detail
Summary
  • Symbol
    Med15
  • Name
    mediator complex subunit 15
  • Synonyms
    A230074L19Rik, Pcqap
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137379
    NCBI Gene: 94112
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17469072-17540811 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1056 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137379
 protein coding gene Chr16:17469072-17550755 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022589
 protein coding gene Chr16:14821901-14896132 (-)
A/J MGP_AJ_G0022550
 protein coding gene Chr16:14085368-14156063 (-)
AKR/J MGP_AKRJ_G0022527
 protein coding gene Chr16:14630354-14701523 (-)
BALB/cJ MGP_BALBcJ_G0022553
 protein coding gene Chr16:14239707-14311348 (-)
C3H/HeJ MGP_C3HHeJ_G0022320
 protein coding gene Chr16:14781785-14855400 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023004
 protein coding gene Chr16:15052879-15130090 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020524
 protein coding gene Chr16:14139068-14214326 (-)
CAST/EiJ MGP_CASTEiJ_G0021848
 protein coding gene Chr16:14688083-14774233 (-)
CBA/J MGP_CBAJ_G0022291
 protein coding gene Chr16:15724079-15799461 (-)
DBA/2J MGP_DBA2J_G0022421
 protein coding gene Chr16:13999779-14071158 (-)
FVB/NJ MGP_FVBNJ_G0022397
 protein coding gene Chr16:14040428-14113463 (-)
LP/J MGP_LPJ_G0022488
 protein coding gene Chr16:14575292-14648442 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022418
 protein coding gene Chr16:15414747-15491386 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023015
 protein coding gene Chr16:14578718-14653533 (-)
PWK/PhJ MGP_PWKPhJ_G0021591
 protein coding gene Chr16:14256126-14329211 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021419
 protein coding gene Chr16:14550343-14624686 (-)
WSB/EiJ MGP_WSBEiJ_G0021895
 protein coding gene Chr16:14566753-14639551 (-)



Homology
more
  • Human Ortholog
    MED15, mediator complex subunit 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MED15, mediator complex subunit 15
  • Synonyms
    ARC105, CAG7A, CTG7A, PCQAP, TIG-1, TIG1, TNRC7
  • Links
    NCBI Gene ID: 51586
    neXtProt AC: NX_Q96RN5
    UniProt: Q96RN5

  • Chr Location
    22q11.21; chr22:20495913-20587632 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MED15 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    861
  • Tissues
    145
  • cDNA Data
    85
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 94112 NCBI Gene Model | MGI Sequence Detail 71740 C57BL/6J ±  kb
transcript NM_001285884 RefSeq | MGI Sequence Detail 3417 ZRU/MplStud  
polypeptide Q924H2 UniProt | EBI | MGI Sequence Detail 789 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    14 Sequences
  • Protein Ontology
    PR:000010287 mediator of RNA polymerase II transcription subunit 15
    (term hierarchy)
  • PDB
    6W1S, 8T1I, 8T1L
  • InterPro Domains
    IPR048385 ARC105/Med15 mediator subunit, central domain
    IPR048386 ARC105/Med15 mediator subunit, C-terminal domain
    IPR036529 Coactivator CBP, KIX domain superfamily
    IPR019087 Mediator of RNA polymerase II transcription subunit 15, N-terminal
  • GlyGen
    Q924H2 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 89
    cDNA 87
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2146647, MGI:2442332
References
more
  • Summaries
    All 45
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:70224 Berti L, et al., Isolation and characterization of a novel gene from the digeorge chromosomal region that encodes for a mediator subunit. Genomics. 2001 Jun 15;74(3):320-32
  • Latest
    J:355262 Kadhim AZ, et al., Transcriptional coactivator MED15 is required for beta cell maturation. Nat Commun. 2024 Oct 8;15(1):8711
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory