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Bpifb1 Gene Detail
Summary
  • Symbol
    Bpifb1
  • Name
    BPI fold containing family B, member 1
  • Synonyms
    2310039C12Rik, LPlunc1, U46068, von Ebner minor salivary protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137431
    NCBI Gene: 228801
  • Alliance
    gene page
  • Transcription Start Sites
    39 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:154032738-154062263 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 76.23 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1005 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137431
 protein coding gene Chr2:154032738-154062289 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026709
 protein coding gene Chr2:158908422-158938808 (+)
A/J MGP_AJ_G0026675
 protein coding gene Chr2:152515470-152552244 (+)
AKR/J MGP_AKRJ_G0026646
 protein coding gene Chr2:157000293-157034316 (+)
BALB/cJ MGP_BALBcJ_G0026685
 protein coding gene Chr2:152862314-152892340 (+)
C3H/HeJ MGP_C3HHeJ_G0026427
 protein coding gene Chr2:157374723-157404214 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027134
 protein coding gene Chr2:163532063-163561544 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024504
 protein coding gene Chr2:146113642-146145132 (+)
CAST/EiJ MGP_CASTEiJ_G0025888
 protein coding gene Chr2:157707396-157744702 (+)
CBA/J MGP_CBAJ_G0026406
 protein coding gene Chr2:169530419-169562867 (+)
DBA/2J MGP_DBA2J_G0026541
 protein coding gene Chr2:151773808-151804283 (+)
FVB/NJ MGP_FVBNJ_G0026507
 protein coding gene Chr2:150184536-150216860 (+)
LP/J MGP_LPJ_G0026646
 protein coding gene Chr2:159005176-159035126 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026529
 protein coding gene Chr2:173559083-173588919 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027189
 protein coding gene Chr2:156881799-156912404 (+)
PWK/PhJ MGP_PWKPhJ_G0025622
 protein coding gene Chr2:151331993-151363977 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025425
 protein coding gene Chr2:155827491-155864338 (+)
WSB/EiJ MGP_WSBEiJ_G0025958
 protein coding gene Chr2:157797649-157828738 (+)



Homology
more
  • Human Ortholog
    BPIFB1, BPI fold containing family B member 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BPIFB1, BPI fold containing family B member 1
  • Synonyms
    C20orf114, LPLUNC1
  • Links
    NCBI Gene ID: 92747
    neXtProt AC: NX_Q8TDL5
    UniProt: Q8TDL5

  • Chr Location
    20q11.21; chr20:33273480-33309871 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit strain background sensitive transmission ratio distortion and increased basal MUC5B production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    28
  • cDNA Data
    10
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 228801 NCBI Gene Model | MGI Sequence Detail 29526 C57BL/6J ±  kb
    transcript NM_001012392 RefSeq | MGI Sequence Detail 1690 Swiss Webster  
    polypeptide Q61114 UniProt | EBI | MGI Sequence Detail 474 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000009898 BPI fold-containing family B member 1
      (term hierarchy)
    • InterPro Domains
      IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain superfamily
      IPR021193 BPI fold-containing family B member 1
      IPR001124 Lipid-binding serum glycoprotein, C-terminal
      IPR017942 Lipid-binding serum glycoprotein, N-terminal
    • GlyGen
      Q61114 4 sites
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 6
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:88670 Hou J, et al., Identification of a novel left-right asymmetrically expressed gene in the mouse belonging to the BPI/PLUNC superfamily. Dev Dyn. 2004 Mar;229(2):373-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory