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Ifi30 Gene Detail
Summary
  • Symbol
    Ifi30
  • Name
    interferon gamma inducible protein 30
  • Synonyms
    GILT, IP30, lysosomal thio reductase IP30 precursor
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137648
    NCBI Gene: 65972
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:71215419-71219307 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137648
 protein coding gene Chr8:71215418-71219307 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033725
 protein coding gene Chr8:71063724-71067616 (-)
A/J MGP_AJ_G0033708
 protein coding gene Chr8:68167430-68171318 (-)
AKR/J MGP_AKRJ_G0033633
 protein coding gene Chr8:70123556-70128422 (-)
BALB/cJ MGP_BALBcJ_G0033704
 protein coding gene Chr8:68403277-68407169 (-)
C3H/HeJ MGP_C3HHeJ_G0033414
 protein coding gene Chr8:70768155-70772047 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034221
 protein coding gene Chr8:73743129-73747017 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031165
 protein coding gene Chr8:62985207-62989074 (-)
CAST/EiJ MGP_CASTEiJ_G0032739
 protein coding gene Chr8:70241509-70245402 (-)
CBA/J MGP_CBAJ_G0033392
 protein coding gene Chr8:76408210-76412102 (-)
DBA/2J MGP_DBA2J_G0033546
 protein coding gene Chr8:67886206-67890098 (-)
FVB/NJ MGP_FVBNJ_G0033487
 protein coding gene Chr8:67023483-67027601 (-)
LP/J MGP_LPJ_G0033633
 protein coding gene Chr8:71084767-71088659 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033530
 protein coding gene Chr8:79036844-79040732 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034239
 protein coding gene Chr8:70301481-70305373 (-)
PWK/PhJ MGP_PWKPhJ_G0032447
 protein coding gene Chr8:67183562-67187450 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032283
 protein coding gene Chr8:69268183-69272063 (-)
WSB/EiJ MGP_WSBEiJ_G0032854
 protein coding gene Chr8:70668780-70672689 (-)



Homology
more
  • Human Ortholog
    IFI30, IFI30 lysosomal thiol reductase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFI30, IFI30 lysosomal thiol reductase
  • Synonyms
    GILT, IFI-30, IP-30, IP30
  • Links
    NCBI Gene ID: 10437
    neXtProt AC: NX_P13284
    UniProt: P13284

  • Chr Location
    19p13.11; chr19:18173162-18178117 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
No phenotypic abormalities have been reported in mice homozygous for disruptions in this gene other than reduced efficiency in processing some antigens.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    10
  • cDNA Data
    6
  • Literature Summary
    1
Sequences &
Gene Models
less
  • All Sequences
    37
  • RefSeq
    2
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031838 Ensembl Gene Model | MGI Sequence Detail 3889 C57BL/6J ±  kb
transcript ENSMUST00000222087 Ensembl | MGI Sequence Detail 980 Not Applicable  
polypeptide ENSMUSP00000159394 Ensembl | MGI Sequence Detail 248 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008905 gamma-interferon-inducible lysosomal thiol reductase
    (term hierarchy)
  • PDB
    6NWX
  • EC
    1.8.-.-
  • InterPro Domains
    IPR004911 Gamma interferon inducible lysosomal thiol reductase GILT
  • GlyGen
    Q9ESY9 3 sites, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 4
References
more
  • Summaries
    All 52
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 24
  • Earliest
    J:71140 Phan UT, et al., Multiple species express thiol oxidoreductases related to GILT. Immunogenetics. 2001 May-Jun;53(4):342-6
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory