Zfhx4 MGI Mouse Gene Detail - MGI:2137668 - zinc finger homeodomain 4

Symbol

Zfhx4
Name

zinc finger homeodomain 4
Synonyms

C130041O22Rik, Zfh-4, Zfh4

Feature Type

protein coding gene
IDs

MGI:2137668
NCBI Gene: 80892
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr3:5283586-5480917 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 1.96 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

4499 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2137668	protein coding gene	Chr3:5276268-5480921 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027045	protein coding gene	Chr3:1976127-2187063 (+)
A/J	MGP_AJ_G0027009	protein coding gene	Chr3:2355733-2554926 (+)
AKR/J	MGP_AKRJ_G0026979	protein coding gene	Chr3:2139328-2336318 (+)
BALB/cJ	MGP_BALBcJ_G0027018	protein coding gene	Chr3:2054514-2264324 (+)
C3H/HeJ	MGP_C3HHeJ_G0026758	protein coding gene	Chr3:2361786-2576100 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027463	protein coding gene	Chr3:2455002-2654440 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024825	protein coding gene	Chr3:1650122-1851228 (+)
CAST/EiJ	MGP_CASTEiJ_G0026217	protein coding gene	Chr3:2441612-2650865 (+)
CBA/J	MGP_CBAJ_G0026737	protein coding gene	Chr3:2178865-2393529 (+)
DBA/2J	MGP_DBA2J_G0026872	protein coding gene	Chr3:1955612-2157572 (+)
FVB/NJ	MGP_FVBNJ_G0026839	protein coding gene	Chr3:1897503-2094014 (+)
LP/J	MGP_LPJ_G0026983	protein coding gene	Chr3:2510596-2725767 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026859	protein coding gene	Chr3:2792323-3036486 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027522	protein coding gene	Chr3:1946676-2148064 (+)
PWK/PhJ	MGP_PWKPhJ_G0025952	protein coding gene	Chr3:2223907-2426409 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025754	protein coding gene	Chr3:2105852-2318240 (+)
WSB/EiJ	MGP_WSBEiJ_G0026288	protein coding gene	Chr3:1982077-2189605 (+)

Human Ortholog

ZFHX4, zinc finger homeobox 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZFHX4, zinc finger homeobox 4
Synonyms

ZFH4, ZHF4
Links

HGNC:30939

NCBI Gene ID: 79776

neXtProt AC: NX_Q86UP3

UniProt: Q86UP3
Chr Location

8q21.13; chr8:76681239-76867281 (+) GRCh38

MGI Vertebrate Homology

Zfhx4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZFHX4
Gene Tree

Zfhx4

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Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

4
Targeted

2
Transposon induced

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

155 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

865
Tissues

97
cDNA Data

11
Literature Summary

21

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ZFHX4

Xenbase zfhx4

ZFIN zfhx4

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All Sequences

57
RefSeq

12
UniProt

7
CCDS

CCDS38382.1

Ensembl

ENSMUSG00000025255 (Evidence)
NCBI Gene

80892

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025255	Ensembl Gene Model \| MGI Sequence Detail	197332	C57BL/6J	± kb
transcript	ENSMUST00000175866	Ensembl \| MGI Sequence Detail	11287	Not Applicable
polypeptide	ENSMUSP00000135827	Ensembl \| MGI Sequence Detail	3606	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000017629 zinc finger homeobox protein 4

(term hierarchy)
PDB

2YRK
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR003604 Matrin/U1-C-like, C2H2-type zinc finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

IPR051968 Zinc finger homeobox transcription regulators

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All nucleic 18

cDNA 14

Primer pair 3

Other 1

Microarray probesets 4

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MGI:2442583

Summaries

All 48

Developmental Gene Expression 21

Gene Ontology 5

Phenotypes 8
Earliest

J:22813 Kostich WA, et al., Expression of zfh-4, a new member of the zinc finger-homeodomain family, in developing brain and muscle. Dev Dyn. 1995 Feb;202(2):145-52
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zfhx4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28265	Chr3:5283576-5283604 (+)	4 bp
Tssr28266	Chr3:5283606-5283621 (+)	28 bp
Tssr28267	Chr3:5283623-5283647 (+)	49 bp
Tssr28268	Chr3:5283650-5283674 (+)	76 bp
Tssr28269	Chr3:5283689-5283744 (+)	131 bp
Tssr28270	Chr3:5283879-5283890 (+)	299 bp
Tssr28271	Chr3:5284085-5284096 (+)	505 bp
Tssr28272	Chr3:5284099-5284113 (+)	520 bp
Tssr28273	Chr3:5284120-5284134 (+)	541 bp
Tssr28274	Chr3:5286108-5286129 (+)	2,533 bp
Tssr28275	Chr3:5286249-5286263 (+)	2,670 bp
Tssr28276	Chr3:5286285-5286305 (+)	2,709 bp
Tssr28277	Chr3:5465657-5465684 (+)	182,085 bp
Tssr28278	Chr3:5465710-5465722 (+)	182,130 bp
Tssr28279	Chr3:5466107-5466111 (+)	182,523 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24