Sfxn3 MGI Mouse Gene Detail - MGI:2137679

Symbol

Sfxn3
Name

sideroflexin 3

Feature Type

protein coding gene
IDs

MGI:2137679
NCBI Gene: 94280
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr19:45036015-45044822 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 38.26 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

278 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2137679	protein coding gene	Chr19:45035942-45044822 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025183	protein coding gene	Chr19:44592563-44602868 (+)
A/J	MGP_AJ_G0025160	protein coding gene	Chr19:42446055-42454855 (+)
AKR/J	MGP_AKRJ_G0025128	protein coding gene	Chr19:43808300-43817314 (+)
BALB/cJ	MGP_BALBcJ_G0025154	protein coding gene	Chr19:42497959-42507191 (+)
C3H/HeJ	MGP_C3HHeJ_G0024914	protein coding gene	Chr19:43969515-43985730 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025597	protein coding gene	Chr19:45681867-45693290 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023011	protein coding gene	Chr19:41713488-41722444 (+)
CAST/EiJ	MGP_CASTEiJ_G0024379	protein coding gene	Chr19:43713154-43723413 (+)
CBA/J	MGP_CBAJ_G0024894	protein coding gene	Chr19:48000006-48012021 (+)
DBA/2J	MGP_DBA2J_G0025026	protein coding gene	Chr19:42265900-42274696 (+)
FVB/NJ	MGP_FVBNJ_G0024987	protein coding gene	Chr19:42032463-42041244 (+)
LP/J	MGP_LPJ_G0025112	protein coding gene	Chr19:44535144-44543892 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025018	protein coding gene	Chr19:47385961-47394901 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025655	protein coding gene	Chr19:43887590-43896390 (+)
PWK/PhJ	MGP_PWKPhJ_G0024128	protein coding gene	Chr19:42173003-42181767 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023932	protein coding gene	Chr19:42577934-42586734 (+)
WSB/EiJ	MGP_WSBEiJ_G0024449	protein coding gene	Chr19:44029925-44040218 (+)

Human Ortholog

SFXN3, sideroflexin 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SFXN3, sideroflexin 3
Synonyms

BA108L7.2, SFX3, SLC56A3
Links

HGNC:16087

NCBI Gene ID: 81855

neXtProt AC: NX_Q9BWM7

UniProt: Q9BWM7
Chr Location

10q24.31; chr10:101031234-101041241 (+) GRCh38

MGI Vertebrate Homology

Sfxn3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SFXN3
Gene Tree

Sfxn3

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Phenotype Summary

2 phenotypes from 1 allele in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

2
Endonuclease-mediated

5
Targeted

4
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit normal mitochondrial bioenergetics in isolated synaptosomes.

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All GO Annotations

19
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

76

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sfxn3

ZFIN sfxn3

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All Sequences

69
RefSeq

15
UniProt

3
CCDS

CCDS29856.1, CCDS50447.1, CCDS50448.1

Ensembl

ENSMUSG00000025212 (Evidence)
NCBI Gene

94280

			Length	Strain/Species	Flank
genomic	94280	NCBI Gene Model \| MGI Sequence Detail	8808	C57BL/6J	± kb
transcript	NM_001362379	RefSeq \| MGI Sequence Detail	3069	C57BL/6
polypeptide	Q91V61	UniProt \| EBI \| MGI Sequence Detail	321	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014778 sideroflexin-3

(term hierarchy)
InterPro Domains

IPR004686 Tricarboxylate/iron carrier
GlyGen

Q91V61 1 site, 1 O-linked glycan (1 site)

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All nucleic 78

cDNA 78

Microarray probesets 3

Summaries

All 40

Gene Ontology 9

Phenotypes 13
Earliest

J:68377 Fleming MD, et al., A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Genes Dev. 2001 Mar 15;15(6):652-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sfxn3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156661	Chr19:45035996-45036011 (+)	-11 bp
Tssr156662	Chr19:45036037-45036109 (+)	58 bp
Tssr156663	Chr19:45036220-45036277 (+)	234 bp
Tssr156664	Chr19:45036284-45036312 (+)	283 bp
Tssr156665	Chr19:45043733-45043747 (+)	7,725 bp
Tssr156666	Chr19:45043798-45043812 (+)	7,790 bp
Tssr156667	Chr19:45044002-45044014 (+)	7,993 bp
Tssr156668	Chr19:45044142-45044174 (+)	8,143 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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