Sfxn4 MGI Mouse Gene Detail - MGI:2137680

Symbol

Sfxn4
Name

sideroflexin 4

Feature Type

protein coding gene
IDs

MGI:2137680
NCBI Gene: 94281
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr19:60825715-60849917 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 56.52 cM, cytoband D3
Mapping Data

2 experiments

SNPs within 2kb

699 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2137680	protein coding gene	Chr19:60824747-60850222 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025297	protein coding gene	Chr19:61447356-61473115 (-)
A/J	MGP_AJ_G0025273	protein coding gene	Chr19:58442891-58467791 (-)
AKR/J	MGP_AKRJ_G0025242	protein coding gene	Chr19:60267619-60296579 (-)
BALB/cJ	MGP_BALBcJ_G0025268	protein coding gene	Chr19:58526616-58552562 (-)
C3H/HeJ	MGP_C3HHeJ_G0025028	protein coding gene	Chr19:60512767-60539045 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025711	protein coding gene	Chr19:62900842-62928193 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023123	protein coding gene	Chr19:57270122-57293551 (-)
CAST/EiJ	MGP_CASTEiJ_G0024493	protein coding gene	Chr19:60615249-60641122 (-)
CBA/J	MGP_CBAJ_G0025008	protein coding gene	Chr19:65963455-65992383 (-)
DBA/2J	MGP_DBA2J_G0025140	protein coding gene	Chr19:58230389-58256446 (-)
FVB/NJ	MGP_FVBNJ_G0025101	protein coding gene	Chr19:57894984-57920426 (-)
LP/J	MGP_LPJ_G0025226	protein coding gene	Chr19:61276713-61304656 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025134	protein coding gene	Chr19:65153774-65184713 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025769	protein coding gene	Chr19:60509157-60534814 (-)
PWK/PhJ	MGP_PWKPhJ_G0024241	protein coding gene	Chr19:58170532-58195261 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024044	protein coding gene	Chr19:59157744-59188485 (-)
WSB/EiJ	MGP_WSBEiJ_G0024563	protein coding gene	Chr19:60618130-60643342 (-)

Human Ortholog

SFXN4, sideroflexin 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SFXN4, sideroflexin 4
Synonyms

BCRM1, COXPD18, SLC56A4
Links

HGNC:16088

NCBI Gene ID: 119559

neXtProt AC: NX_Q6P4A7

UniProt: Q6P4A7
Chr Location

10q26.11

MGI Vertebrate Homology

Sfxn4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SFXN4
Gene Tree

Sfxn4

Diseases

1 with human SFXN4 associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 18 IDs combined oxidative phosphorylation deficiency 18 DOID:0111484 OMIM:615578 ORDO:391348

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available

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All GO Annotations

13
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

15
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sfxn4

ZFIN sfxn4

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All Sequences

49
RefSeq

14
UniProt

3
CCDS

CCDS29943.1

Ensembl

ENSMUSG00000063698 (Evidence)
NCBI Gene

94281

			Length	Strain/Species	Flank
genomic	ENSMUSG00000063698	Ensembl Gene Model \| MGI Sequence Detail	24203	C57BL/6J	± kb
transcript	ENSMUST00000135808	Ensembl \| MGI Sequence Detail	1309	Not Applicable
polypeptide	ENSMUSP00000118743	Ensembl \| MGI Sequence Detail	313	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014779 sideroflexin-4

(term hierarchy)
InterPro Domains

IPR004686 Tricarboxylate/iron carrier

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All nucleic 15

cDNA 15

Microarray probesets 3

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 6
Earliest

J:68377 Fleming MD, et al., A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Genes Dev. 2001 Mar 15;15(6):652-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sfxn4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160078	Chr19:60849828-60849900 (-)	53 bp
Tssr160077	Chr19:60849094-60849097 (-)	821 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24