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Loxl2 Gene Detail
Summary
  • Symbol
    Loxl2
  • Name
    lysyl oxidase-like 2
  • Synonyms
    1110004B06Rik, 9430067E15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137913
    NCBI Gene: 94352
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:69846517-69933283 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.06 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    687 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137913
 protein coding gene Chr14:69846085-69933283 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021522
 protein coding gene Chr14:64169225-64267050 (+)
A/J MGP_AJ_G0021481
 protein coding gene Chr14:62649529-62950944 (+)
AKR/J MGP_AKRJ_G0021457
 protein coding gene Chr14:64743078-64834069 (+)
BALB/cJ MGP_BALBcJ_G0021487
 protein coding gene Chr14:62624315-62711186 (+)
C3H/HeJ MGP_C3HHeJ_G0021264
 protein coding gene Chr14:64469813-64557134 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021926
 protein coding gene Chr14:67090148-67183974 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019466
 protein coding gene Chr14:60709185-60796973 (+)
CAST/EiJ MGP_CASTEiJ_G0020781
 protein coding gene Chr14:61010575-61106060 (+)
CBA/J MGP_CBAJ_G0021231
 protein coding gene Chr14:69185907-69280777 (+)
DBA/2J MGP_DBA2J_G0021354
 protein coding gene Chr14:62247982-62335289 (+)
FVB/NJ MGP_FVBNJ_G0021333
 protein coding gene Chr14:61664459-61754148 (+)
LP/J MGP_LPJ_G0021424
 protein coding gene Chr14:65510890-65539024 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021362
 protein coding gene Chr14:68130753-68222449 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021949
 protein coding gene Chr14:64007844-64097312 (+)
PWK/PhJ MGP_PWKPhJ_G0020525
 protein coding gene Chr14:58997639-59089189 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020358
 protein coding gene Chr14:59930349-60028246 (+)
WSB/EiJ MGP_WSBEiJ_G0020834
 protein coding gene Chr14:64306929-64394664 (+)



Homology
more
  • Human Ortholog
    LOXL2, lysyl oxidase like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LOXL2, lysyl oxidase like 2
  • Synonyms
    LOR, LOR2, WS9-14
  • Links
    NCBI Gene ID: 4017
    neXtProt AC: NX_Q9Y4K0
    UniProt: Q9Y4K0

  • Chr Location
    8p21.3; chr8:23296897-23425328 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show partial perinatal lethality associated with cardiac defects and distended liver blood vessels. Overexpressing mice display male sterility, testis degeneration, epididymal dysfunction, and increased tumor burden and malignant progression after DMBA-TPA treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    11
  • cDNA Data
    10
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034205 Ensembl Gene Model | MGI Sequence Detail 86767 C57BL/6J ±  kb
    transcript ENSMUST00000022660 Ensembl | MGI Sequence Detail 5316 Not Applicable  
    polypeptide ENSMUSP00000022660 Ensembl | MGI Sequence Detail 776 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1915706, MGI:2443992
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 7
      Gene Ontology 11
      Phenotypes 17
    • Earliest
      J:52798 Jang W, et al., Comparative sequence of human and mouse BAC clones from the mnd2 region of chromosome 2p13. Genome Res. 1999 Jan;9(1):53-61
    • Latest
      J:354593 Wang H, et al., Sex differences and role of lysyl oxidase-like 2 in angiotensin II-induced hypertension in mice. Am J Physiol Heart Circ Physiol. 2024 Sep 1;327(3):H642-H659
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory