Smap1 MGI Mouse Gene Detail - MGI:2138261

Symbol

Smap1
Name

small ArfGAP 1
Synonyms

1700056O10Rik, 4921514B13Rik, 4921525H11Rik

Feature Type

protein coding gene
IDs

MGI:2138261
NCBI Gene: 98366
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:23883927-23961398 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 9.79 cM, cytoband A5
Mapping Data

3 experiments

SNPs within 2kb

1965 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138261	protein coding gene	Chr1:23883925-23961462 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0015886	protein coding gene	Chr1:21673676-21745613 (-)
A/J	MGP_AJ_G0015867	protein coding gene	Chr1:21243551-21314912 (-)
AKR/J	MGP_AKRJ_G0015824	protein coding gene	Chr1:21458603-21540862 (-)
BALB/cJ	MGP_BALBcJ_G0015823	protein coding gene	Chr1:20982181-21061585 (-)
C3H/HeJ	MGP_C3HHeJ_G0015657	protein coding gene	Chr1:21465093-21542398 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016277	protein coding gene	Chr1:22640479-22714501 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013996	protein coding gene	Chr1:19322274-19398779 (-)
CAST/EiJ	MGP_CASTEiJ_G0015236	protein coding gene	Chr1:21574457-21652701 (-)
CBA/J	MGP_CBAJ_G0015629	protein coding gene	Chr1:23187583-23267948 (-)
DBA/2J	MGP_DBA2J_G0015728	protein coding gene	Chr1:20729016-20809169 (-)
FVB/NJ	MGP_FVBNJ_G0015732	protein coding gene	Chr1:20498942-20569394 (-)
LP/J	MGP_LPJ_G0015800	protein coding gene	Chr1:21872717-21951467 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015752	protein coding gene	Chr1:24205256-24283093 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016324	protein coding gene	Chr1:21355443-21432851 (-)
PWK/PhJ	MGP_PWKPhJ_G0015019	protein coding gene	Chr1:20492674-20567455 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014800	protein coding gene	Chr1:21472353-21552572 (-)
WSB/EiJ	MGP_WSBEiJ_G0015299	protein coding gene	Chr1:21301725-21375791 (-)

Human Ortholog

SMAP1, small ArfGAP 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SMAP1, small ArfGAP 1
Synonyms

SMAP-1
Links

HGNC:19651

NCBI Gene ID: 60682

neXtProt AC: NX_Q8IYB5

UniProt: Q8IYB5
Chr Location

6q13; chr6:70667776-70862015 (+) GRCh38

MGI Vertebrate Homology

Smap1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SMAP1
Gene Tree

Smap1

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Phenotype Summary

28 phenotypes from 1 allele in 1 genetic background
4 phenotypes from multigenic genotypes
6 images
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

5
Targeted

6
Genomic Mutations

1 involving Smap1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit perturbed receptor trafficking and myelodysplasia.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

10
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase smap1

ZFIN smap1

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All Sequences

53
RefSeq

9
UniProt

2
CCDS

CCDS14851.1, CCDS69870.1

Ensembl

ENSMUSG00000026155 (Evidence)
NCBI Gene

98366

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026155	Ensembl Gene Model \| MGI Sequence Detail	77472	C57BL/6J	± kb
transcript	ENSMUST00000027339	Ensembl \| MGI Sequence Detail	2289	Not Applicable
polypeptide	ENSMUSP00000027339	Ensembl \| MGI Sequence Detail	440	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015258 stromal membrane-associated protein 1

(term hierarchy)
InterPro Domains

IPR051718 ADP Ribosylation Factor GTPase-Activating

IPR038508 ArfGAP domain superfamily

IPR037278 ARFGAP/RecO-like zinc finger

IPR001164 Arf GTPase activating protein

IPR044732 SMAP1-like, ArfGAP domain

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All nucleic 12

cDNA 12

Microarray probesets 6

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MGI:1918153, MGI:1918155, MGI:1920661

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 12
Earliest

J:79308 Sato Y, et al., Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment. J Biochem. 1998 Jul;124(1):209-16
Latest

J:226700 Sumiyoshi M, et al., Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality. FEBS Lett. 2015 Sep 14;589(19 Pt B):2754-62

TSS for Smap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11130	Chr1:23961475-23961519 (-)	-99 bp
Tssr11129	Chr1:23961451-23961472 (-)	-64 bp
Tssr11128	Chr1:23961364-23961447 (-)	-8 bp
Tssr11127	Chr1:23961333-23961362 (-)	50 bp
Tssr11126	Chr1:23948815-23948821 (-)	12,580 bp
Tssr11125	Chr1:23948768-23948787 (-)	12,620 bp
Tssr11124	Chr1:23930990-23931007 (-)	30,399 bp
Tssr11123	Chr1:23916851-23916864 (-)	44,540 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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