Sh3bp4 MGI Mouse Gene Detail - MGI:2138297 - SH3-domain binding protein 4

Symbol

Sh3bp4
Name

SH3-domain binding protein 4
Synonyms

BOG25

Feature Type

protein coding gene
IDs

MGI:2138297
NCBI Gene: 98402
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:88998137-89082790 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 45.05 cM
Mapping Data

1 experiment

SNPs within 2kb

2046 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138297	protein coding gene	Chr1:88998061-89082940 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016289	protein coding gene	Chr1:90520717-90601424 (+)
A/J	MGP_AJ_G0016270	protein coding gene	Chr1:87269155-87348105 (+)
AKR/J	MGP_AKRJ_G0016231	protein coding gene	Chr1:89850191-89931549 (+)
BALB/cJ	MGP_BALBcJ_G0016226	protein coding gene	Chr1:87412431-87492715 (+)
C3H/HeJ	MGP_C3HHeJ_G0016055	protein coding gene	Chr1:90065209-90146092 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016685	protein coding gene	Chr1:94035765-94122648 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014403	protein coding gene	Chr1:81562368-81643107 (+)
CAST/EiJ	MGP_CASTEiJ_G0015640	protein coding gene	Chr1:89378098-89463614 (+)
CBA/J	MGP_CBAJ_G0016031	protein coding gene	Chr1:97021195-97103213 (+)
DBA/2J	MGP_DBA2J_G0016134	protein coding gene	Chr1:86492317-86572180 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0016205	protein coding gene	Chr1:91660032-91741119 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016158	protein coding gene	Chr1:100359074-100438499 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016725	protein coding gene	Chr1:89877914-89956810 (+)
PWK/PhJ	MGP_PWKPhJ_G0015424	protein coding gene	Chr1:85889873-85970100 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015207	protein coding gene	Chr1:88766485-88850150 (+)
WSB/EiJ	MGP_WSBEiJ_G0015698	protein coding gene	Chr1:89592664-89673026 (+)

Human Ortholog

SH3BP4, SH3 domain binding protein 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SH3BP4, SH3 domain binding protein 4
Synonyms

BOG25, TTP
Links

HGNC:10826

NCBI Gene ID: 23677

neXtProt AC: NX_Q9P0V3

UniProt: Q9P0V3
Chr Location

2q37.2; chr2:234952017-235055714 (+) GRCh38

MGI Vertebrate Homology

Sh3bp4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SH3BP4
Gene Tree

Sh3bp4

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

91
Chemically induced (other)

1
Gene trapped

87
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Sh3bp4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

173 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

29
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

3
cDNA Data

12
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sh3bp4

ZFIN sh3bp4a

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All Sequences

60
RefSeq

10
UniProt

1
CCDS

CCDS15147.1

Ensembl

ENSMUSG00000036206 (Evidence)
NCBI Gene

98402

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036206	Ensembl Gene Model \| MGI Sequence Detail	84654	C57BL/6J	± kb
transcript	ENSMUST00000066279	Ensembl \| MGI Sequence Detail	4995	Not Applicable
polypeptide	ENSMUSP00000067581	Ensembl \| MGI Sequence Detail	962	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014820 SH3 domain-binding protein 4

(term hierarchy)
InterPro Domains

IPR035456 SH3BP4, SH3 domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR000906 ZU5 domain
GlyGen

Q921I6 1 site, 1 N-linked glycan (1 site)

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All nucleic 13

cDNA 13

Microarray probesets 5

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MGI:2138581

Summaries

All 47

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 19
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sh3bp4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7982	Chr1:88998086-88998093 (+)	-47 bp
Tssr7983	Chr1:88998128-88998143 (+)	-1 bp
Tssr7984	Chr1:88998161-88998179 (+)	33 bp
Tssr7985	Chr1:88998197-88998211 (+)	67 bp
Tssr7986	Chr1:89031490-89031505 (+)	33,361 bp
Tssr7987	Chr1:89048583-89048588 (+)	50,449 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24