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Trp53bp2 Gene Detail
Summary
  • Symbol
    Trp53bp2
  • Name
    transformation related protein 53 binding protein 2
  • Synonyms
    53BP2, ASPP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138319
    NCBI Gene: 209456
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:182236737-182289997 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 84.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1482 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138319
 protein coding gene Chr1:182236737-182289997 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016894
 protein coding gene Chr1:189035967-189092796 (+)
A/J MGP_AJ_G0016873
 protein coding gene Chr1:181330915-181385388 (+)
AKR/J MGP_AKRJ_G0016838
 protein coding gene Chr1:186708423-186760884 (+)
BALB/cJ MGP_BALBcJ_G0016831
 protein coding gene Chr1:181964717-182018759 (+)
C3H/HeJ MGP_C3HHeJ_G0016655
 protein coding gene Chr1:187523398-187577574 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017294
 protein coding gene Chr1:195138347-195193049 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015001
 protein coding gene Chr1:172401708-172455639 (+)
CAST/EiJ MGP_CASTEiJ_G0016237
 protein coding gene Chr1:186867170-186921038 (+)
CBA/J MGP_CBAJ_G0016629
 protein coding gene Chr1:202368243-202436050 (+)
DBA/2J MGP_DBA2J_G0016735
 protein coding gene Chr1:180109264-180162757 (+)
FVB/NJ MGP_FVBNJ_G0016731
 protein coding gene Chr1:178240644-178299593 (+)
LP/J MGP_LPJ_G0016810
 protein coding gene Chr1:190231002-190286524 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016763
 protein coding gene Chr1:209388042-209443677 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017331
 protein coding gene Chr1:186532889-186588948 (+)
PWK/PhJ MGP_PWKPhJ_G0016025
 protein coding gene Chr1:179295796-179350245 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015801
 protein coding gene Chr1:185488652-185547727 (+)
WSB/EiJ MGP_WSBEiJ_G0016300
 protein coding gene Chr1:186726946-186782766 (+)



Homology
more
  • Human Ortholog
    TP53BP2, tumor protein p53 binding protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TP53BP2, tumor protein p53 binding protein 2
  • Synonyms
    53BP2, ASPP2, BBP, P53BP2, PPP1R13A
  • Links
    NCBI Gene ID: 7159
    neXtProt AC: NX_Q13625
    UniProt: Q13625

  • Chr Location
    1q41; chr1:223779893-223845954 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Trp53bp2 mouse models

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    76 phenotypes from 4 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation is lethal by 30 days of age, although majority die embryonically. Heterozygotes show increased susceptibility to spontaneous and induced tumors of the lymphoma and sarcoma types
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    846
  • Tissues
    131
  • cDNA Data
    102
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 209456 NCBI Gene Model | MGI Sequence Detail 53261 C57BL/6J ±  kb
    transcript NM_173378 RefSeq | MGI Sequence Detail 4361 C57BL/6  
    polypeptide Q8CG79 UniProt | EBI | MGI Sequence Detail 1128 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000016559 apoptosis-stimulating of p53 protein 2
      (term hierarchy)
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR047163 Apoptosis-stimulating of p53 protein 1/2
      IPR048942 Apoptosis-stimulating of p53 protein 2-like, RA domain
      IPR047166 Apoptosis-stimulating protein of p53 protein 2, RA domain
      IPR001452 SH3 domain
      IPR036028 SH3-like domain superfamily
      IPR029071 Ubiquitin-like domain superfamily
    • GlyGen
      Q8CG79 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 105
      cDNA 102
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138737
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 7
      Phenotypes 22
    • Earliest
      J:38063 Sowden JC, et al., The identification of novel sequences expressed in the mouse notochord. Mamm Genome. 1997 Jan;8(1):42-4
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory